Table 2.
BsAbs bridge two cells in clinical stages.
| Bridge immune cell | Bridge tumor cell | Name | Indication | Phase | Clinical trial |
|---|---|---|---|---|---|
| CD3 | BCMA | BI836909 | R/R MM | Ⅰ | NCT03287908 |
| CD123 | APVO436 | AML | Ⅰ | NCT03647800 | |
| CD19 | AMG562 | DLBCL | Ⅰ | NCT03571828 | |
| CD20 | GEN3013 | DLBCL | Ⅰ/Ⅱ | NCT03625037 | |
| CD33 | GEM333 | AML | Ⅰ | NCT03516760 | |
| CD38 | GBR1342 | R/R MM | Ⅰ | NCT03309111 | |
| CEA | RG7802 | Solid tumors | Ⅰ | NCT02650713 | |
| CLEC12A | MCLA-117 | AML | Ⅰ | NCT03038230 | |
| DLL3 | AMG757 | AML | Ⅰ | NCT03541369 | |
| EGFR | AFM24 | Advanced solid tumor | Ⅰ/Ⅱ | NCT04259450 | |
| EpCAM | MT110 | Solid tumors | Ⅰ | NCT00635596 | |
| FcRH5 | RO7187797 | MM | Ⅰ | NCT03275103 | |
| FLT3 | AMG427 | AML | Ⅰ | NCT03541369 | |
| GD2 | NCT03541369 | SCLC | Ⅰ/Ⅱ | NCT04750239 | |
| Glypican-3 | ERY974 | Solid tumors | Ⅰ | NCT02748837 | |
| gpA33 | MGD007 | Colorectal carcinoma | Ⅰ | NCT02248805 | |
| GPRC5D | ERY974 | Solid tumors | Ⅰ | NCT02748837 | |
| HER2 | BTRC4017A | Solid tumors | Ⅰ | NCT03448042 | |
| MAGE-A4 (HLA-A∗02:01) | IMC-C103C | Select advanced solid tumors | Ⅰ/Ⅱ | NCT03973333 | |
| MUC17 | AMG199 | MUC17-positive solid tumors | Ⅰ | NCT04117958 | |
| MUC16 | REGN4018 | Recurrent ovarian cancer | Ⅰ/Ⅱ | NCT03564340 | |
| NY-ESO-1 (HLA-A∗02:01) | GSK01 | Select advanced solid tumors | Ⅰ/Ⅱ | NCT03515551 | |
| P-cadherin | PF-06671008 | Neoplasms | Ⅰ | NCT02659631 | |
| PRAME (HLA-A∗02:01) | IMC-F106C | Select advanced solid tumors | Ⅰ/Ⅱ | NCT04262466 | |
| PSCA | GEM3PSCA | NSCLC | Ⅰ | NCT03927573 | |
| PSMA | JNJ-63898081 | Neoplasms | Ⅰ | NCT03926013 | |
| SSTR2 | Xmab18087 | Neuroendocrine tumor | Ⅰ | NCT03411915 | |
| STEAP1 | AMG509 | Prostate cancer | Ⅰ | NCT04221542 | |
| 5T4 | GEN1044 | Malignant solid tumors | Ⅰ/Ⅱ | NCT04424641 | |
| γδTCR | CD1d | LAVA-051 | CLL | Ⅰ/Ⅱ | NCT04887259 |
| PSMA | LAVA-1207 | Metastatic castration resistant prostate cancer | Ⅰ/Ⅱ | NCT05369000 | |
| CD16A | BCMA | RO7297089 | R/R MM | Ⅰ | NCT04434469 |
| CD30 | AFM13 | NHL | Ⅰ/Ⅱ | NCT04074746 | |
| EGFR | AFM24 | Advanced solid tumor | Ⅰ/Ⅱ | NCT04259450 |
AML, acute myeloid leukemia; CLL, chronic lymphocytic leukemia; DLBCL, diffuse large B-cell lymphoma; MM, multiple myeloma; NHL, non-Hodgkin lymphoma; NSCLC, non-small-cell lung carcinoma; R/R MM, relapsed or refractory multiple myeloma; SCLC, small-cell carcinoma.