Table 4.
BsAbs bridge cytokines or cytokines/receptors in clinical stages.
| Classification | Target | Name | Indication | Phase | Clinical trial |
|---|---|---|---|---|---|
| Cytokines × receptors | TGF-β × CD73 | GS-1423 | Advanced solid tumors | Ⅰ | NCT03954704 |
| TGF-β × PD-L1 | SHR-1701 | Squamous cell carcinoma of head and neck | Ⅱ | NCT04650633 | |
| TGF-β × EGFR | BCA101 | Head and neck squamous cell carcinoma | Ⅰ | NCT04429542 | |
| VEGF × DLL4 | OMP-305B83 | Metastatic colorectal cancer | Ⅰ | NCT03035253 | |
| VEGF × PD-1 | AK112 | NSCLC | Ⅰ/Ⅱ | NCT04900363 | |
| Cytokines × cytokines | VEGF × Ang-2 | Vanucizumab | Advanced solid tumors | Ⅰ | NCT02665416 |