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. 2023 Jun 23;30(9):1285–1295. doi: 10.1038/s41417-023-00637-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — EWS IGF2BP3 positive parental cells (on the left) or IGF2BP3-silenced cells (on the right) were used as recipient cells. Data from three independent experiments of cells receiving IGF2BP3pos or IGF2BP3neg EVs are shown. a Migration of A673 parental cells after exposure to its own EVs (CTR), or shNC EVs versus IGF2BP3neg EVs extracted from A673#18 or #54. Histograms represent the ratio ± SE of migrated cells compared to CTR. *p < 0.05, One-way ANOVA with respect to CTR. b Migration of IGF2BP3-silenced A673#18 cells after exposure to its own EVs (CTR) versus IGF2BP3pos EVs extracted from the parental A673 cells. Histograms represent the ratio ± SE of migrated cells compared to CTR. *p < 0.05, Student t-test. c Migration of TC-71 parental cells after exposure to its own EVs (CTR), or shNC EVs versus IGF2BP3neg EVs extracted from TC-71#46 or #73 cells. Histograms represent the ratio ± SE of migrated cells compared to CTR. **p < 0.01,***p < 0.001, One-way ANOVA with respect to CTR. d Migration of IGF2BP3-silenced cell line TC-71#46 after exposure to its own EVs (CTR) versus IGF2BP3pos EVs extracted from the parental TC-71 cells. Histograms represent the ratio ± SE of migrated cells compared to CTR. *p < 0.05, Student t-test. e Migration of TC-71 parental cells after exposure to IGF2BP3pos EVs extracted from EW#5-C cells versus IGF2BP3neg EVs extracted from EW#5-C sg-IGF2BP3-1 cells. Histograms represent the ratio ± SE of migrated cells compared to TC-71 treated with EW#5-C EVs. **p < 0.01, Student t-test. f Migration of IGF2BP3-silenced cell line TC-71#46 after exposure to IGF2BP3neg EVs extracted from EW#5-C sg-IGF2BP3-1 versus IGF2BP3pos EVs extracted from parental EW#5-C. Histograms represent the ratio ± SE of migrated cells compared to TC-71#46 cells treated with sg-IGF2BP3-1. **p < 0.01, Student t-test.