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. 2023 Jun 2;30(9):1234–1248. doi: 10.1038/s41417-023-00633-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Violin plots showing significant LBH expression changes across different tumor stages in multiple cancer types. (i–vi) Cancer types with increased LBH expression levels in the later tumor stages (III/IV) were: (i) COAD - colon adenocarcinoma, (ii) READ - rectum adenocarcinoma, (iii) ESCA - esophageal carcinoma, (iv) STAD - stomach adenocarcinoma, (v) BLCA - bladder urothelial carcinoma, and (vi) KIRC - kidney renal clear cell carcinoma. (vii–ix) Cancer types with decreased LBH expression in the later stages were: (vii) LUAD - lung adenocarcinoma, (viii) SKCM - skin cutaneous melanoma, and (ix) CESC Cervical squamous cell carcinoma. Violin plots were generated from GEPIA2. One-way ANOVA test: P-values as indicated. B–C Kaplan–Meier plots showing overall and relapse-free survival of patients with high (red) and low (blue) intra-tumoral LBH expressions in: B LBH-overexpressing, and C LBH-underexpressing cancer types. The TCGA-GEPIA, R2 platform (R2), and Kaplan–Meier (KM) plotter patient cohorts used, and the number (n) of cases with LBH high and low expression are indicated. Log-rank test: P-values (threshold p < 0.05) and Hazard Ratios (HR), as indicated. OS overall survival, RFS relapse-free survival, EFS event-free survival. See also Fig. S2.