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. 2023 Jun 2;30(9):1234–1248. doi: 10.1038/s41417-023-00633-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A, B Co-expression and correlation analysis of LBH with WNT/Integrin pathway genes. A Heatmaps of LBH and correlated genes in a representative colorectal cancer dataset from Oncomine (Skrzypczak_Colorectal-GSE20916). Blue signifies low, and red equals high mRNA expression. Pearson correlation coefficients between LBH and indicated genes are listed. B Dot plots showing correlations between LBH expression and expression of key WNT pathway genes in colon cancer based on TCGA data. Pearson correlation coefficients (R-values) and P-values, as indicated. See also Figs. S6, S7, S8. C Kaplan−Meier plot of overall survival in colon cancer patients (n = 270) stratified by the LBH/WNT/Integrin signatures. Multivariate Cox regression analysis of COAD patient data from TCGA. Log-rank test: P-values and Hazard Ratios (HR), as indicated. See also Table S6.