Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Aug 10;3(9):1144–1166. doi: 10.1038/s43587-023-00462-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 4 — These tissue-specific universal clocks were constructed in an analogous fashion to the pan-tissue clocks described in the main text. The panels show leave-one-fraction-out (LOFO) estimates (y-axis) of four clocks: universal blood clock 2 (Universal BloodClock 2) which estimates relative age, universal blood clock 3 (Universal BloodClock 3) which estimates log-linear transformation of age. Analogously, we defined Universal SkinClock2 and Universal SkinClock3. Relative age estimation incorporates maximum lifespan and gestational age and assumes values between 0 and 1. Log-linear age is formulated with age at sexual maturity and gestational time. a, c, e, g, LOFO estimates of DNAm age (y-axis, in units of years) based on transforming relative age (Clock 2) or log-linear age (Clock 3). b, f, d, h, transformed age (x-axis) versus corresponding DNAm estimates (y-axis). The title of each panel reports the Pearson correlation coefficient across all data points and the median correlation (med.Cor) and median of median absolute error (med.MAE) across all species. Each sample is labeled by mammalian species index (explained in Fig. 2) and colored by taxonomic order. The legend reports the taxonomic order and the mammalian order index as a prefix.