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. 2023 Aug 10;3(9):1144–1166. doi: 10.1038/s43587-023-00462-6

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — We studied the overlapping genomic regions between (1) the CpG sites located in the binding regions of 68 transcription factors (TF) in hg19 and (2) the top 1000 CpGs that increased/decreased with age from EWAS of age across mammalian tissues. TF results (y-axis, rows) versus mammalian EWAS of age are stratified by tissue type (x-axis, columns). The left/right panels of the x-axis list the top 1000 CpGs that increased/decreased with age from meta-EWAS of age across all tissues, blood only, skin only, liver, muscle, brain and cerebral cortex, respectively. The y-axis lists the names of transcription factors and number of mammalian array CpGs located in the binding sites. Background in hypergeometric tests was based on the genes present in our mammalian array. The bar plots in the first column report the total number of genes at each TF according to the background. The heatmap color codes -log10 (unadjusted hypergeometric P value). Unadjusted, one-sided hypergeometric P values (odds ratio) are listed on the heatmap provided P < 0.05.