Table 3.
Associations of dichotomized biomarkers of systemic inflammatory response with all-cause and cause-specific mortality
| Mortality | Biomarkers of systemic inflammatory response, HR (95% CI), N = 397,737 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| CRP > 2.75 mg/L | mGPS ≥ 1 | HS_mGPS ≥ 1 | NLR > 2.78 | PLR > 237 | LMR < 2.56 | SII > 717 | PNI < 50 | NPS ≥ 1 | |
| All-cause mortality (Ndeaths = 29,548) | |||||||||
| Adjusted for age and sex | 1.76 (1.72, 1.80) | 2.18 (2.10, 2.27) | 1.77 (1.73, 1.82) | 1.48 (1.45, 1.52) | 1.54 (1.48, 1.61) | 1.54 (1.49, 1.58) | 1.48 (1.45, 1.52) | 1.52 (1.47, 1.56) | 2.24 (2.14, 2.34) |
| Plus BMI and waist circumference | 1.57 (1.54, 1.61) | 1.91 (1.83, 1.99) | 1.59 (1.55, 1.64) | 1.47 (1.43, 1.51) | 1.62 (1.55, 1.69) | 1.52 (1.48, 1.57) | 1.47 (1.43, 1.50) | 1.51 (1.46, 1.55) | 2.10 (2.01, 2.19) |
| Plus vitamin D status | 1.56 (1.52, 1.60) | 1.89 (1.81, 1.97) | 1.58 (1.54, 1.62) | 1.46 (1.42, 1.49) | 1.61 (1.54, 1.68) | 1.53 (1.48, 1.57) | 1.45 (1.41, 1.48) | 1.50 (1.46, 1.55) | 2.04 (1.95, 2.13) |
| CVD mortality (Ndeaths = 6,091) | |||||||||
| Adjusted for age and sex | 2.00 (1.90, 2.11) | 2.28 (2.09, 2.5) | 2.04 (1.93, 2.15) | 1.68 (1.60, 1.77) | 1.37 (1.24, 1.52) | 1.68 (1.58, 1.78) | 1.64 (1.55, 1.72) | 1.51 (1.41, 1.62) | 2.56 (2.34, 2.80) |
| Plus BMI and waist circumference | 1.61 (1.53, 1.70) | 1.79 (1.64, 1.96) | 1.64 (1.55, 1.73) | 1.67 (1.58, 1.75) | 1.51 (1.36, 1.67) | 1.66 (1.56, 1.77) | 1.61 (1.53, 1.70) | 1.50 (1.40, 1.60) | 2.32 (2.12, 2.54) |
| Plus vitamin D status | 1.60 (1.51, 1.69) | 1.77 (1.62, 1.94) | 1.62 (1.54, 1.71) | 1.65 (1.57, 1.74) | 1.50 (1.35, 1.66) | 1.66 (1.56, 1.77) | 1.59 (1.51, 1.68) | 1.50 (1.40, 1.60) | 2.24 (2.05, 2.46) |
| Cancer mortality (Ndeaths = 14,895) | |||||||||
| Adjusted for age and sex | 1.62 (1.57, 1.67) | 1.89 (1.78, 2.01) | 1.62 (1.57, 1.68) | 1.30 (1.26, 1.35) | 1.51 (1.42, 1.61) | 1.38 (1.32, 1.45) | 1.34 (1.29, 1.39) | 1.38 (1.32, 1.45) | 1.77 (1.66, 1.9) |
| Plus BMI and waist circumference | 1.52 (1.47, 1.58) | 1.75 (1.65, 1.86) | 1.53 (1.47, 1.58) | 1.30 (1.26, 1.35) | 1.56 (1.47, 1.66) | 1.38 (1.32, 1.44) | 1.33 (1.29, 1.38) | 1.39 (1.32, 1.45) | 1.70 (1.59, 1.82) |
| Plus vitamin D status | 1.52 (1.46, 1.57) | 1.74 (1.64, 1.85) | 1.52 (1.46, 1.57) | 1.29 (1.25, 1.34) | 1.56 (1.46, 1.66) | 1.38 (1.32, 1.44) | 1.32 (1.28, 1.37) | 1.38 (1.32, 1.45) | 1.67 (1.57, 1.79) |
| Respiratory mortality (Ndeaths = 2,086) | |||||||||
| Adjusted for age and sex | 2.73 (2.51, 2.98) | 3.73 (3.30, 4.22) | 2.75 (2.52, 2.99) | 2.02 (1.85, 2.20) | 2.15 (1.87, 2.48) | 2.03 (1.83, 2.25) | 2.25 (2.06, 2.45) | 1.82 (1.63, 2.03) | 4.75 (4.21, 5.37) |
| Plus BMI and waist circumference | 2.63 (2.40, 2.88) | 3.25 (2.87, 3.67) | 2.61 (2.39, 2.86) | 1.96 (1.79, 2.14) | 2.16 (1.87, 2.49) | 1.97 (1.78, 2.19) | 2.19 (2.01, 2.39) | 1.76 (1.57, 1.96) | 4.35 (3.85, 4.92) |
| Plus vitamin D status | 2.59 (2.37, 2.84) | 3.19 (2.82, 3.62) | 2.56 (2.34, 2.80) | 1.93 (1.77, 2.10) | 2.13 (1.85, 2.46) | 1.98 (1.78, 2.19) | 2.14 (1.96, 2.33) | 1.76 (1.58, 1.96) | 4.13 (3.65, 4.67) |
BMI, body mass index; CI, confidence interval; CRP, C-reactive protein; CVD, cardiovascular disease; HR, hazard ratio; HS_mGPS, High-sensitive mGPS; LMR, lymphocyte-to-monocyte ratio; mGPS, modified Glasgow prognostic score; NLR, neutrophil-to-lymphocyte ratio; NPS, neutrophil-platelet score; PLR, platelet-to-lymphocyte ratio; PNI, prognostic nutritional index; SII, systemic immune-inflammation index