Table 6.

Hazard ratios for the association of 25(OH)D levels per 5 nmol/L with mortality outcomes among subjects with vitamin D deficiency with and without adjustment for biomarkers of systemic inflammatory response, N=83,929

HR (95% CI) per 5 nmol/L increase of 25(OH)D levels in subjects with vitamin D deficiency (25(OH)D < 30 nmol/L)
	Covariates adjusted for
Mortality	Model 4a	Model 4 + CRP	Model 4 + mGPS	Model 4 + HS_mGPS	Model 4 + NLR	Model 4 + PLR	Model 4 + LMR	Model 4 + SII	Model 4 + PNI	Model 4 + NPS
All-cause (Ndeaths = 7736)	0.87 (0.85, 0.89)	0.87 (0.86, 0.89)	0.87 (0.85, 0.89)	0.87 (0.86, 0.89)	0.87 (0.86, 0.90)	0.88 (0.86, 0.90)	0.88 (0.86, 0.90)	0.88 (0.86, 0.90)	0.87 (0.85, 0.89)	0.87 (0.86, 0.90)
CVD (Ndeaths = 1706)	0.86 (0.82, 0.90)	0.86 (0.82, 0.90)	0.86 (0.82, 0.90)	0.86 (0.82, 0.90)	0.86 (0.82, 0.90)	0.86 (0.82, 0.90)	0.86 (0.82, 0.90)	0.86 (0.82, 0.91)	0.86 (0.82, 0.90)	0.86 (0.82, 0.90)
Cancer (Ndeaths = 3481)	0.91 (0.88, 0.94)	0.91 (0.88, 0.94)	0.91 (0.88, 0.94)	0.91 (0.88, 0.95)	0.91 (0.88, 0.94)	0.91 (0.88, 0.95)	0.91 (0.88, 0.94)	0.91 (0.88, 0.95)	0.91 (0.88, 0.94)	0.91 (0.88, 0.94)
Respiratory (Ndeaths = 661)	0.79 (0.73, 0.86)	0.79 (0.74, 0.86)	0.79 (0.73, 0.86)	0.79 (0.73, 0.86)	0.80 (0.74, 0.86)	0.80 (0.74, 0.86)	0.80 (0.74, 0.86)	0.80 (0.74, 0.87)	0.79 (0.73, 0.86)	0.80 (0.74, 0.86)

25(OH)D, 25-hydroxyvitamin D; CI, confidence interval; CRP, C-reactive protein; HR, hazard ratio; HS_mGPS, High-sensitive mGPS; LMR, lymphocyte-to-monocyte ratio; mGPS, modified Glasgow prognostic score; NA, not applicable; NLR, neutrophil-to-lymphocyte ratio; NPS, neutrophil-platelet score; PLR, platelet-to-lymphocyte ratio; PNI, prognostic nutritional index; SII, systemic immune-inflammation index

^aThe model is adjusted for covariates in Model 4 (see legend of Table 4)