Table 2.

Frequency of the most commonly reported adverse reactions associated with cenobamate based on a pooled analysis of tolerability data from two randomised, double-blind, placebo-controlled trials [101, 102] as reported in the prescribing information [77]. The Table includes reactions reported for any cenobamate arm with a frequency ≥5% over placebo

Adverse reaction	Placebo (n = 216) (%)	Cenobamate 100 mg/day (n = 108) (%)	Cenobamate 200 mg/day (n = 223) (%)	Cenobamate 400 mg/day (n = 111) (%)
Somnolence	11	19	22	37
Dizziness	15	18	22	33
Fatigue	7	12	14	24
Diplopia	2	6	7	15
Balance disorder	1	3	5	9
Nausea	3	6	6	9
Constipation	0	2	4	8
Gait disturbance	1	1	3	8
Nystagmus	0	3	7	6
Dysarthria	0	2	1	7
Vertigo	1	1	1	6
Vomiting	0	2	4	5
Diarrhoea	0	1	3	5