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. 2023 Sep 14;6:942. doi: 10.1038/s42003-023-05330-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Proteins immunoprecipitated from the hearts of HA-Speg mice using antibodies against the HA-tag and identified by mass spectrometry (n = 6 for each). b Effects of Speg deficiency on the levels of Fsd2 (n = 8 for each) and Esd (n = 9 for each) in homogenates from hearts of Speg-KO mice. A representative western blot is shown on the left. c Effects of Speg deficiency on the levels of Fsd2 and Esd in homogenates from hearts of HA-Speg mice (n = 6 for each). d Heatmap of specific RyR2 binding proteins from the hearts of control and Speg-KO mice (n = 9 for each). e Proteins that are significantly changed the cardiac RyR2 IP from controls compared Speg-KO mice. f Proteins that are significantly changed the cardiac RyR2 IP from controls compared HA-Speg mice (n = 6 for each). g Heatmap of specific Jph2-binding proteins from the hearts of control and Speg-KO mice (n = 9 for each). h Proteins that are significantly changed the cardiac Jph2 IPs from controls compared Speg-KO mice. i Proteins that are significantly changed the cardiac Jph2 IPs from controls compared HA-Speg mice (n = 6 for each). j Effect of Speg deficiency on the relative amounts of Esd, Cmya5 and Fsd2 in the cardiac Jph2 IP from Speg-KO mice. k Effect of Speg deficiency on the relative amounts of Esd, Cmya5, and Fsd2 in the cardiac Jph2 IP from HA-Speg mice. l Model summarizing the findings from the proteomic studies in cardiac muscle. Data are plotted as the mean ± SD. ****P < 0.0001, ***P < 0.001, **P < 0.01, and *P < 0.05.