Table 2.
Comparisons of baseline characteristics of four classes.
| Variables | Class 1 (n = 496) |
Class 2 (n = 100) |
Class 3 (n = 313) |
Class 4 (n = 555) |
p-value |
|---|---|---|---|---|---|
| Age, (years) | 63.9 ± 16.4 | 61 ± 18.7 | 61.1 ± 17.3 | 64.5 ± 16.1 | 0.011 |
| Sex, men (%) | 326 (65.7) | 71 (71) | 233 (74.4) | 327 (58.9) | < 0.001 |
| Hypertension (%) | 229 (46.2) | 48 (48) | 150 (47.9) | 259 (46.7) | 0.96 |
| Diabetes (%) | 84 (16.9) | 14 (14) | 48 (15.3) | 90 (16.2) | 0.868 |
| COPD (%) | 49 (9.9) | 6 (6) | 24 (7.7) | 96 (17.3) | < 0.001 |
| RRT (%) | 35 (7.1) | 7 (7) | 49 (15.7) | 43 (7.7) | < 0.001 |
| SOFA score | 6.5 ± 3 | 7 ± 3.3 | 7.2 ± 3.3 | 6.5 ± 3.1 | 0.018 |
| APACHE-II score | 20.4 ± 6.2 | 20.8 ± 5.7 | 20.6 ± 6.2 | 19.8 ± 6.3 | 0.18 |
| Laboratory indexes on first ICU admission day | |||||
| White blood cell count, (× 109/L) | 13 ± 6.8 | 11.6 ± 5.4 | 12.6 ± 6.7 | 12.7 ± 6.3 | 0.242 |
| Lymphocyte count, (× 109/L) | 0.9 ± 0.6 | 0.9 ± 0.6 | 0.9 ± 0.6 | 0.9 ± 0.6 | 0.209 |
| Neutrophil count, (× 109/L) | 11.5 ± 6.4 | 10.1 ± 4.9 | 10.9 ± 6.2 | 11.3 ± 5.9 | 0.175 |
| Platelet count, (× 109/L) | 158.8 ± 75.2 | 160.6 ± 72.1 | 161.1 ± 75.5 | 168 ± 79.4 | 0.244 |
| C-reactive protein, (mg/L) | 108.95 (35.67, 160.62) | 19.5 (7.34, 59.99) | 127.9 (37.3, 184.2) | 47.61 (11.71, 81.1) | < 0.001 |
| Procalcitonin, (ug/L) | 13.1 ± 38.1 | 16.8 ± 55 | 18.3 ± 41.5 | 8.9 ± 33.2 | 0.005 |
| pH | 7.4 ± 0.1 | 7.4 ± 0.1 | 7.4 ± 0.1 | 7.4 ± 0.1 | 0.3 |
| PCO2, (mmHg) | 35.6 ± 7.5 | 36 ± 6.2 | 35.8 ± 7.5 | 37.4 ± 10.4 | 0.003 |
| PO2, (mmHg) | 144.3 ± 57.3 | 157.3 ± 60.5 | 148 ± 59 | 140.2 ± 55.7 | 0.026 |
| Lactate, (mmol/L) | 2.7 ± 2 | 2.8 ± 1.8 | 2.9 ± 2.1 | 2.6 ± 2.2 | 0.264 |
| Prothrombin time, (s) | 15.2 (14.2, 16.6) | 15.5 (14, 16.7) | 15.1 (14.1, 16.5) | 14.7 (13.7, 16.2) | 0.002 |
| APTT, (s) | 40.4 (35.6, 46.6) | 39.8 (35.7, 45.23) | 39.2 (35.9, 44.9) | 39.1 (35, 45.7) | 0.305 |
| D-dimer, (μg/L) | 4.78 (2.13, 12.22) | 5.14 (1.8, 10.77) | 4.45 (2.55, 10.34) | 3.79 (1.63, 8.38) | < 0.001 |
| Creatinine, (mmol/L) | 96.3 ± 72.4 | 99.2 ± 78.5 | 112.9 ± 88.1 | 98.2 ± 81 | 0.024 |
COPD, chronic obstructive pulmonary disease; UTI, urinary tract infection; RRT, renal replacement therapy; SOFA, sequential organ failure assessment; APACHE, Acute Physiology and Chronic Health Evaluation; ICU, intensive care unit; PCO2, partial pressure of carbon dioxide; PO2, partial pressure of oxygen; APTT, activated partial thromboplastin time.