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. 2023 Sep 14;13:15234. doi: 10.1038/s41598-023-42504-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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sEH inhibition bidirectionally gates glutamate synapses of CA1 pyramidal neurons. (A) Inhibition of sEH potentiates eEPSC amplitude in CA1 pyramidal neurons. Left graph is a summary of the time course and magnitude of the potentiation of EPSCs induced by TPPU (10 µM). Right panel depicts the average of at least thirty pairs of EPSCs collected at the time points indicated by the numbers in the left panel. Scale bars: 25 ms, 100 pA. (B) Averaged PPR of EPSCs obtained at baseline and during TPPU application. (C) Averaged CV of EPSCs obtained in absence and presence of TPPU. (D) Inhibition of sEH depresses eEPSC amplitude in CA1 pyramidal neurons. Left graph is a summary of the time course and magnitude of the depression of EPSCs induced by TPPU (10 µM). Right panel depicts the average of at least thirty pairs of EPSCs collected at the time points indicated by the numbers in the left panel. Scale bars: 25 ms, 100 pA. (E) Averaged PPR obtained in the absence and presence of TPPU. (F) Averaged CV of EPSCs obtained in absence and presence of TPPU.