. Author manuscript; available in PMC: 2024 Sep 1.

Published in final edited form as: Alzheimers Dement. 2023 Mar 15;19(9):3815–3825. doi: 10.1002/alz.13014

Table 3.

Discriminative performance of plasma Aβ_42/40 ratio as a function of BBB permeability.

	AUC (95% CI)
	Entire sample	High BBB permeability	Low BBB permeability
CSF Aβ positivity (TRIAD)	0.655 (0.51 – 0.77)	0.992 (0.95 – 1)^a,b	0.591 (0.42 – 0.76)
Aβ-PET positivity (TRIAD)	0.585 (0.45 – 0.71)	0.984 (0.94 –1)^a,b	0.607 (0.45 – 0.78)
CSF Aβ positivity (BIODEGMAR)	0.779 (0.69 – 0.86)	0.836 (0.71 – 0.95)	0.76 (0.62 – 0.89)

Abbreviations: Aβ: Amyloid-β; AUC: area under the curve; BBB: blood-brain barrier; CSF: cerebrospinal fluid; PET: positron emission tomography; ROC: receiver operating characteristic. AUC differences were tested using the DeLong test followed by false discovery rate multiple comparison correction.

^a:

P< 0.0001 compared to entire sample;

^b:

P< 0.0001 compared to low BBB permeability.