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. 2023 Sep 1;14:1213734. doi: 10.3389/fphar.2023.1213734

TABLE 2.

Neonatal related indicators of four groups.

Parameters Group I (n = 38) Group II (n = 10) Group III (n = 10) Group IV (n = 14) p-Value
Full-term singleton Premature singleton Term twins Premature twins
Weight, g 3397 ± 452 2359 ± 536a 2544 ± 260a 2102 ± 357 ac 0.000
Neonatal asphyxia 2 (5.25%) 3 (30%) 0 (0%) 5 (35.71%) ac 0.008
1 min Apgar scores 9.53 ± 1.03 8.40 ± 1.84 9.80 ± 0.42 8.07 ± 2.62 0.007
Muscle tone (0/1/2) 0/5/33 0/4/6 0/1/9 1/4/9 0.117
Heart rate (0/1/2) 0/1/37 0/1/9 0/0/10 0/2/12 0.276
Reflex (0/1/2) 0/0/38 0/1/9 0/0/10 0/3/11a 0.016
Color (0/1/2) 0/5/33 0/4/6 0/1/9 0/7/7a 0.014
Respiration (0/1/2) 1/5/32 1/4/5 0/0/10 2/3/9 0.056
5 min Apgar scores 9.92 ± 0.36 9.50 ± 1.08 10.00 ± 0.00 9.27 ± 1.49 0.049
Muscle tone (0/1/2) 0/2/36 0/2/8 0/0/10 0/2/12 0.218
Heart rate (0/1/2) 0/0/38 0/0/10 0/0/10 0/0/14
Reflex (0/1/2) 0/0/38 0/0/10 0/0/10 0/1/13 0.472
Color (0/1/2) 0/0/38 0/2/8a 0/0/10 0/4/10a 0.002
Respiration (0/1/2) 0/1/37 0/1/9 0/0/10 1/1/12 0.328
10 min Apgar scores 9.97 ± 0.16 9.80 ± 0.42 10.00 ± 0.00 9.71 ± 0.83 0.163
Muscle tone (0/1/2) 0/1/37 0/2/8 0/0/10 0/1/13 0.147
Heart rate (0/1/2) 0/0/38 0/0/10 0/0/10 0/0/14
Reflex (0/1/2) 0/0/38 0/0/10 0/0/10 0/0/14
Color (0/1/2) 0/0/38 0/0/10 0/0/10 0/0/14
Respiration (0/1/2) 0/0/38 0/0/10 0/0/10 1/1/12 0.219
Tactile stimulation 38 10 10 14
Bag-mask ventilation 4 6a 0b 6 ac 0.001
Tracheal intubation 0 1 0 3a 0.019
NICU (Yes/No) 5/33 9/1a 1/9b 12/2ac 0.000
UA blood pH 7.28 ± 0.05 7.26 ± 0.05 7.27 ± 0.05 7.23 ± 0.04a 0.037
UA blood PaO2 (mmHg) 31.69 ± 13.03 29.70 ± 13.37 31.38 ± 8.50 28.79 ± 12.51 0.898
UA blood PaCO2, (mmHg) 55.17 ± 7.55 57.79 ± 9.08 49.00 ± 7.03 56.14 ± 8.46 0.125
UA blood Base excess (mmol/L) −2.04 ± 1.89 −2.46 ± 2.51 −4.86 ± 1.55a −4.75 ± 2.96a 0.001

NICU, neonatal intensive care unit, UA, umbilical artery.

a: Compared with Group I, p < 0.05; b: Compared with Group II, p < 0.05; c: Compared with Group III, p < 0.05.