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. 2023 Aug 4;299(9):105133. doi: 10.1016/j.jbc.2023.105133

Figure 3.

Figure 3

RBM12 impacts the cAMP and transcriptional signaling steps independently.A, PCK1 mRNA expression in untreated cells or in cells treated with either 1 μM isoproterenol (WT cells) or 10 nM isoproterenol (RBM12 KO cells) for 1 h (n = 3). B, PCK1 mRNA expression in untreated cells or in cells treated with 150 μM 8-CPT-cAMP for 1 h (n = 4). All data are mean ± SD. Statistical significance was determined using two-way ANOVA with Tukey’s correction (A and B). See also Fig. S3. ∗∗∗∗ = p < 0.0001, ∗ = p < 0.05. RBM, RNA-binding motif.