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. 2023 Aug 31;26(10):107802. doi: 10.1016/j.isci.2023.107802

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© 2023 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Transcriptomic analysis of NGMCs and NE1-GMCs

Gene set enrichment analysis (GSEA) between NE1-GMCs purified with CD8 microbeads and NGMCs under unstimulated and stimulated conditions was performed.

(A) Heatmap of rank metric scores and plots of the enrichment scores for the “ WP electron transport chain: oxphos system in mitochondria” gene set in the unstimulated and TCR-stimulated states are shown.

(B) Heatmap of rank metric scores and plots of the enrichment scores for the “WP oxidative phosphorylation” gene set in the TCR-stimulated state are shown. The “unstimulated” rank metric score shows unstimulated NE1-GMCs versus unstimulated NGMCs, and the “stimulated” rank metric score shows NE1-pMHC-stimulated NE1-GMCs versus IMMU510-stimulated NGMCs. Rank metric score >0 (red) means higher in NE1-GMCs, <0 (blue) means lower in NE1-GMCs, compared with NGMCs. One sample per group was analyzed.