Table 1.
Summary of gene set enrichment analysis (GSEA): detected mitochondrial metabolism-related gene sets
| Gene set | SIZE | Unstimulated NE1-GMCs per unstimulated NGMCs |
NE1-pMHC-stimulated NE1-GMCs per IMMU510-stimulated NGMCs |
||||||
|---|---|---|---|---|---|---|---|---|---|
| ES | NES | NOM p value | FDR q-value | ES | NES | NOM p value | FDR q-value | ||
| WP_MITOCHONDRIAL_COMPLEX_III_ASSEMBLY | 15 | 0.69 | 1.44 | 0.057 | 1.000 | 0.53 | 1.07 | 0.401 | 1.000 |
| WP_ELECTRON_TRANSPORT_CHAIN_OXPHOS_SYSTEM_IN_MITOCHONDRIA | 90 | 0.45 | 1.33 | 0.042 | 1.000 | 0.55 | 1.57 | 0.004 | 1.000 |
| WP_GLYCOGEN_SYNTHESIS_AND_DEGRADATION | 40 | 0.50 | 1.30 | 0.109 | 1.000 | 0.52 | 1.31 | 0.117 | 1.000 |
| WP_TCA_CYCLE_AND_DEFICIENCY_OF_PYRUVATE_DEHYDROGENASE_COMPLEX_PDHC | 16 | 0.61 | 1.29 | 0.153 | 1.000 | 0.66 | 1.36 | 0.113 | 1.000 |
| WP_MITOCHONDRIAL_COMPLEX_I_ASSEMBLY_MODEL_OXPHOS_SYSTEM | 49 | 0.46 | 1.23 | 0.134 | 1.000 | 0.38 | 1.00 | 0.401 | 1.000 |
| WP_OXIDATIVE_PHOSPHORYLATION | 52 | 0.42 | 1.13 | 0.230 | 1.000 | 0.58 | 1.54 | 0.006 | 1.000 |
| WP_MITOCHONDRIAL_COMPLEX_IV_ASSEMBLY | 31 | 0.47 | 1.13 | 0.272 | 1.000 | 0.55 | 1.31 | 0.112 | 1.000 |
| WP_TCA_CYCLE_AKA_KREBS_OR_CITRIC_ACID_CYCLE | 18 | 0.50 | 1.09 | 0.346 | 1.000 | 0.57 | 1.22 | 0.194 | 1.000 |
ES, Enrichment Score; FDR, False discovery rate; NE1-GMCs, genetically modified γδ-T cells expressing an NY-ESO-1-specific αβ-TCR and the CD8 coreceptor; NES, Normalized Enrichment Score; NE1-pMHC, NY-ESO-1p157-165 peptide and HLA-A∗02:01 complex; NGMCs, non-gene-modified γδ-T cells; NOM, Nominal.