REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
See Table S1.
Chemicals, peptides, and recombinant proteins
Doxycycline hyclate	Sigma-Aldrich	Cat# D9891
MG-132 (Z-Leu-Leu-Leu-al)	Sigma-Aldrich	Cat# C2211
OSMI-1	Sigma-Aldrich	Cat# SML1621
NMS-873	Sigma-Aldrich	Cat# SML1128
Tunicamycin	Enzo Life Sciences	Cat# BML-CC104-0010
Puromycin	Enzo Life Sciences	Cat# BML-GR312-0250
Bortezomib	LC Laboratories	Cat# B-1408
TAK-243	Lucerna-chem	Cat# HY-100487
CP-26	Anawa	Cat# AOB13238-1
Proteinase K	Roche	Cat# 03115887001
Critical commercial assays
Phusion High-Fidelity PCR kit	New England BioLabs	Cat# E0553
Pfu DNA Polymerase	Promega	Cat# M774A
2X Reverse Transcription master mix	Applied Biosystems	Cat# 4368814
Deposited data
Raw sequencing data RNA-seq	NCBI	BioProject ID PRJNA897493
Raw mass spectrometry data	ProteomeXchange Consortium	ID PXD041331 10.6019/PXD041331
Raw data for immunoblots	Mendeley	https://doi.org/10.17632/dcxmrzdkvk.1
Experimental models: Cell lines
HEK293T (Female)	Jürg Tschopp	N/A
ARH77 (Female)	Pascal Schneider	N/A
HeLa (Female)	Pascal Schneider	N/A
See Table S2.
Oligonucleotides
See Table S3.
Recombinant DNA
pCR3	Pascal Schneider	N/A
pDONR-221	Thermo Fisher Scientific	Cat# 12536017
pINDUCER-21	Stephen Elledge and Thomas Westbrook	N/A
pLentiCRISPRv2-Puro	Sanjana et al.42	RRID:Addgene_52961
Software and Algorithms
CRISPRseek Bioconductor package	Zhu et al.43	https://doi.org/10.18129/B9.bioc.CRISPRseek