Table 2.
Characterization of recurrent strokes/TIAs, and bleeding events post-index event
| Events | All patients (N = 985) | Kept same DOAC regimen (n = 623) | Changed DOAC dose (n = 83) | Changed DOAC agent (n = 155) | Changed to warfarin (n = 51) | No OAC prescription filled (n = 73) |
|---|---|---|---|---|---|---|
| Patients with recurrent stroke/TIA | 135 (14) | 75 (12) | 13 (16) | 16 (10) | 8 (16) | 23 (32) |
| Recurrent event type | ||||||
| Stroke∗ | 66 (49) | 34 (45) | 6 (46) | 7 (44) | 4 (50) | 15 (65) |
| TIA∗ | 69 (51) | 41 (55) | 7 (54) | 9 (56) | 4 (50) | 8 (35) |
| Days to recurrent event, median (IQR) | 244 (439) | 388 (635) | 115 (209) | 282 (314) | 245 (513) | 17 (32) |
| Patients with bleeding event | 46 (5) | 28 (4) | 2 (2) | 8 (5) | 3 (6) | 5 (7) |
| Bleeding location | ||||||
| ICH† or SAH† | 11 (24) | 4 (14) | 0 (0) | 2 (25) | 1 (33) | 4 (80) |
| Gastrointestinal† | 29 (63) | 20 (72) | 2 (100) | 4 (50) | 2 (67) | 1 (20) |
| Other†,‡ | 10 (22) | 4 (14) | 0 (0) | 2 (25) | 0 (0) | 0 (0) |
| Days to bleeding event, median (IQR) | 536 (773) | 504 (749) | 1104 (2131) | 663 (372) | 1002 (2434) | 60 (53) |
Values are n (%), unless otherwise indicated.
DOAC, direct OAC; ICH, intracranial hemorrhage; IQR, interquartile range; OAC, oral anticoagulant; SAH, subarachnoid hemorrhage; TIA, transient ischemic attack.
∗
Percentages are expressed as a proportion of all patients or patients in each prescribing strategy with a recurrent stroke or TIA.
†
Percentages are expressed as a proportion of all patients or patients in each prescribing strategy with a bleeding event.
‡
Other: genitourinary, other critical areas including intraspinal, intraocular, retroperitoneal, intraarticular and pericardial hemorrhage, other areas including epistaxis and hemothorax.