Table 1.

Comparison of differentially expressed genes in response to SF in BG and HG involved in glutathione metabolism and the antioxidant response.

Gene Symbol	Ensembl ID	Gene	Basal Glucose		High Glucose
			Folda Change	q-valueb	Folda Change	Qvalueb
GCLC	ENSG00000001084	Glutamate-cysteine ligase catalytic subunit	4.2	<0.001	4.4	<0.001
GCLM	ENSG00000023909	Glutamate-cysteine ligase regulatory subunit	6.0	<0.001	5.0	<0.001
GLRX	ENSG00000173221	Glutaredoxin-1	1.3	0.04	1.8	<0.0001
GPX2	ENSG00000176153	Glutathione Peroxidase 2	2.0	0.04	2.8	0.007
GSR	ENSG00000104687	Glutathione reductase	2.3	<0.001	2.3	<0.001
SLC7A11	ENSG00000151012	Cysteine/Glutamate transporter	2.7	0.04	2.7	0.007
SRXN1	ENSG00000271303	Sulfiredoxin 1	5.4	<0.001	5.4	<0.001
TXN	ENSG00000136810	Thioredoxin	1.8	<0.001	1.9	0.001
TXNRD1	ENSG00000198431	Thioredoxin reductase 1	2.0	<0.001	4.6	0.002

^aFold change of SF treated cells compared to DMSO control.

^bq-values were determined through Benjamini-Hochberg p-value adjustment