Table 2.

Comparison of differentially expressed genes in response to SF in BG and HG involved in 1C Metabolism, Pentose Phosphate Pathway and Glycolysis.

Gene Symbol	Ensembl ID	Gene	Basal Glucose		High Glucose
			Folda Change	q-valueb	Folda Change	Qvalueb
PHGDH	ENSG00000092621	Phosphoglycerate dehydrogenase	−1.7	0.005	−1.6	0.01
GLDC	ENSG00000178445	Glycine decarboxylase	−1.4	0.005	−1.3	0.01
GNMT	ENSG00000124713	Glycine-N-methyltransferase	−7.0	0.001	3.0	0.03
ALDH1L1	ENSG00000144908	10-formyltetrahydrofolate dehydrogenase	1.9	<0.001	2.3	<0.001
MTHFD1L	ENSG00000120254	monofunctional C1-tetrahydrofolate	1.3	0.01	1.3	0.04
BHMT2	ENSG00000132840	betaine--homocysteine S-methyltransferase 2	3.6	<0.001	3.2	<0.001
G6PD	ENSG00000160211	Glucose-6-Phosphate Dehydrogenase	1.2	0.3	1.6	0.01
TKT	ENSG00000163931	Transketolase	1.5	0.02	1.7	0.005
TALDO1	ENSG00000177156	Transaldolase 1	2.0	<0.001	2.2	<0.001
ENO3	ENSG00000108515	Enolase	−2.3	<0.001	−1.7	0.01
PGM1	ENSG00000079739	Phosphoglucomutase-1	−1.5	0.004	−1.4	0.01
GCKR	ENSG00000084734	Glucose kinase regulatory protein	2.4	<0.001	2.4	<0.001

^aFold change of SF treated cells compared to DMSO control.

^bq-values were determined through Benjamini-Hochberg p-value adjustment