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. 2023 Sep 7;67:102878. doi: 10.1016/j.redox.2023.102878

Table 3.

Comparison of differentially expressed genes in response to SF in the WT and NRF2-KD HepG2 cell lines involved in the antioxidant response, PPP, glycolysis, glycine serine and threonine metabolism.

Gene Symbol
 Ensembl ID
 Gene
 Wild type
 NRF2KD
Folda Change q-valueb Folda Change Qvalueb
GCLC ENSG00000001084 Glutamate-cysteine ligase catalytic subunit 3.2 <0.001 1.3 <0.001
GCLM ENSG00000023909 Glutamate-cysteine ligase regulatory subunit 4.1 <0.001 1.4 <0.001
SLC7A11 ENSG00000151012 Cysteine/Glutamate transporter 3.3 <0.001 1.6 <0.001
GPX2 ENSG00000176153 Glutathione Peroxidase 2 2.0 <0.001 1.0 0.92
GSR ENSG00000104687 Glutathione Reductase 2.2 <0.001 1.2 <0.001
TXN ENSG00000136810 Thioredoxin 2.0 <0.001 1.0 0.99
TXNRD1 ENSG00000198431 Thioredoxin reductase 1 4.3 <0.001 1.4 <0.001
G6PD ENSG00000160211 Glucose-6-Phosphate Dehydrogenase 1.5 <0.001 1.0 0.60
PGD ENSG00000142657 Phosphogluconate dehydrogenase 1.5 <0.001 1.0 0.94
RPE ENSG00000197713 ribulose-5-phosphate-3-epimerase 1.2 <0.001 1.0 0.01
TALDO1 ENSG00000177156 Transaldolase 1 2.2 <0.001 1.1 <0.001
TKT ENSG00000163931 Transketolase 1.7 <0.001 1.1 0.41
GPI ENSG00000105220 Glucose Phosphate Isomerase 1.3 <0.001 1.0 <0.001
PFKP ENSG00000067057 Phospho Fructo Kinase platelet 1.7 <0.001 1.1 0.41
ALDOA ENSG00000149925 Aldolase A 1.5 <0.001 1.1 0.10
PRPS1 ENSG00000147224 Phosphoribosyl pyrophosphate synthase 1 1.3 <0.001 1.1 0.21
PHGDH ENSG00000092621 Phosphoglycerate Dehydrogenase −1.2 <0.001 −1.0 <0.001
PSPH ENSG00000146733 Phosphoserine Phosphatase −1.4 <0.001 −1.0 <0.001
GLDC ENSG00000178445 Glycine Decarboxylase −1.3 <0.001 −1.1 <0.001
GNMT ENSG00000124713 Glycine-N-methyl transferase −2.9 <0.001 −2 <0.001
ALDH1L1 ENSG00000144908 Aldehyde Dehydrogenase family 1 member L1 2.3 <0.001 1.0 0.60
MTHFD1L ENSG00000120254 Methylenetetrahydrofolate dehydrogenase 1.3 <0.001 1.1 0.02
BHMT2 ENSG00000132840 betaine--homocysteine S-methyltransferase 2 2.3 <0.001 1.3 <0.001
a

Fold change of SF treated cells compared to DMSO control.

b

q-values were determined through Benjamini-Hochberg p-value adjustment