Table 2.
Adverse events across all dose levels and cycles (regardless of attribution) occurring in more than 10% of patients or grade 3 or higher events.
| Adverse event term | Grade 1–2, n (%) | Grade 3–4, n (%) | All grades, n (%) | |
|---|---|---|---|---|
| Hematologic | Anemia | 1 | 6 | 7 (33%) |
| Platelet count decreased | 3 | 4 | 7 (33%) | |
| Neutrophil count decreased | 3 | 3 (14%) | ||
| White blood cell decreased | 2 | 2 (10%) | ||
| Leukocytosis | 1 | 1 | 2 (10%) | |
| Nonhematologic | Pruritus | 9 | 9 (43%) | |
| Fatigue | 7 | 1 | 8 (38%) | |
| Abdominal pain | 7 | 7 (33%) | ||
| Diarrhea | 6 | 6 (29%) | ||
| Edema limbs | 5 | 5 (24%) | ||
| Nausea | 5 | 5 (24%) | ||
| Epistaxis | 4 | 1 | 5 (24%) | |
| Hyperuricemia | 5 | 5 (24%) | ||
| Gastrointestinal disorders | 2 | 2 | 4 (19%) | |
| Creatinine increased | 4 | 4 (19%) | ||
| AST increased | 3 | 3 (14%) | ||
| Pain | 4 | 4 (19%) | ||
| Dizziness | 4 | 4 (19%) | ||
| Cough | 3 | 3 (14%) | ||
| Dyspnea | 3 | 3 (14%) | ||
| Hypomagnesmia | 3 | 3 (14%) | ||
| Hypocalcemia | 2 | 1 | 3 (14%) | |
| Headache | 3 | 3 (14%) | ||
| Muscle cramps | 3 | 3 (14%) | ||
| Anorexia | 3 | 3 (14%) | ||
| Hyponatremia | 3 | 3 (14%) | ||
| Vomiting | 3 | 3 (14%) | ||
| Palpitations | 3 | 3 (14%) | ||
| Rash maculopapular | 2 | 1 | 3 (14%) | |
| Mucositis | 2 | 1 | 3 (14%) | |
| Urinary tract infection | 1 | 1 | 2 (10%) | |
| Duodenal hemorrhage | 1 | 1 (5%) | ||
| Gastric hemorrhage | 1 | 1 (5%) | ||
| Extraocular muscle paresis | 1 | 1 (5%) | ||
| Syncope | 1 | 1 (5%) |