Table 3. Univariate and multivariate regression of factors affecting DFS using Cox regression.
| Characteristics | Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|
| β | P | HR (95% CI) | β | P | HR (95% CI) | ||
| Female/Male | 0.002 | 0.977 | 0.918 (0.828, 1.019) | −0.119 | 0.044 | 0.888 (0.792, 0.997) | |
| Age, years | <0.001 | <0.001 | |||||
| 45–54/<45 | −0.035 | 0.726 | 0.966 (0.796, 1.173) | 0.164 | 0.107 | 1.178 (0.965, 1.438) | |
| 55–64/<45 | −0.021 | 0.813 | 0.979 (0.821, 1.167) | 0.208 | 0.027 | 1.231 (1.024, 1.481) | |
| 65–74/<45 | 0.071 | 0.448 | 1.074 (0.894, 1.290) | 0.190 | 0.056 | 1.210 (0.995, 1.471) | |
| 75+/<45 | 0.558 | <0.001 | 1.748 (1.435, 2.129) | 0.684 | <0.001 | 1.982 (1.600, 2.454) | |
| Laparoscope/open surgery | 0.002 | 0.977 | 1.002 (0.877, 1.145) | −0.213 | 0.006 | 0.808 (0.693, 0.942) | |
| pTNM | <0.001 | <0.001 | |||||
| II/I | 0.458 | <0.001 | 1.582 (1.310, 1.909) | 0.398 | <0.001 | 1.489 (1.227, 1.808) | |
| III/I | 1.205 | <0.001 | 3.336 (2.805, 3.966) | 0.891 | <0.001 | 2.437 (2.025, 2.933) | |
| Site | 0.018 | 0.005 | |||||
| Left colon/rectum | −0.195 | 0.005 | 0.823 (0.719, 0.942) | −0.225 | 0.001 | 0.798 (0.696, 0.916) | |
| Right colon/rectum | −0.039 | 0.550 | 0.961 (0.845, 1.093) | −0.069 | 0.349 | 0.933 (0.808, 1.079) | |
| Histological type | <0.001 | 0.003 | |||||
| Mucinous adenocarcinoma/adenocarcinoma | 0.199 | 0.013 | 1.220 (1.044, 1.426) | 0.200 | 0.014 | 1.221 (1.041, 1.432) | |
| Signet-ring cell carcinoma/adenocarcinoma | 0.917 | <0.001 | 2.501 (1.905, 3.284) | 0.384 | 0.009 | 1.467 (1.099, 1.959) | |
| EMVI+/− | 0.871 | <0.001 | 2.389 (2.149, 2.657) | 0.508 | <0.001 | 1.662 (1.474, 1.874) | |
| PNI+/− | 0.810 | <0.001 | 2.249 (2.019, 2.505) | 0.489 | <0.001 | 1.631 (1.451, 1.833) | |
| CRM+/− | 1.460 | <0.001 | 4.305 (3.177, 5.832) | 0.954 | <0.001 | 2.595 (1.898, 3.548) | |
| General anesthesia combined with epidural anesthesia | −0.020 | 0.708 | 0.980 (0.883, 1.088) | ||||
| ASA score | 0.002 | ||||||
| II/I | 0.143 | 0.011 | 1.153 (1.034, 1.287) | ||||
| III–V/I | 0.448 | 0.002 | 1.565 (1.178, 2.079) | ||||
| Neutrophil-lymphocyte ratio | 0.018 | 0.001 | 1.018 (1.007, 1.029) | ||||
| Lymphocyte-monocyte ratio | −0.077 | <0.001 | 0.926 (0.902, 0.950) | −0.041 | 0.005 | 0.960 (0.933, 0.987) | |
| Hemoglobin (g/L) | −0.007 | <0.001 | 0.993 (0.991, 0.995) | −0.006 | <0.001 | 0.994 (0.991, 0.997) | |
| Albumin (g/L) | −0.041 | <0.001 | 0.960 (0.948, 0.973) | −0.017 | 0.040 | 0.984 (0.968, 0.999) | |
| Operation duration | 0.004 | <0.001 | 1.004 (1.003, 1.005) | 0.005 | <0.001 | 1.005 (1.003, 1.006) | |
| Number of lymph nodes examined | −0.037 | <0.001 | 0.964 (0.953, 0.974) | −0.031 | <0.001 | 0.970 (0.961, 0.979) | |
The category after the “/” is the reference category. DFS, disease-free survival; pTNM, pathological tumor-node-metastasis; EMVI, external vascular invasion; PNI, perineural invasion; CRM, circumferential resection margin; ASA, American Society of Anesthesiologists.