Table 1.
Overall characteristics of patients with tumefactive demyelination.
| Characteristic | All TD (n = 257) | TMS (n = 183) | TD (n = 62) | MOGAD (n = 12) |
|---|---|---|---|---|
| Female | 147 (57%) | 101 (55%) | 39 (63%) | 7 (58%) |
| White race | 205 (89%) | 146 (90%) | 52 (91%) | 7 (64%) |
| Mean age at index attack ± SD | 38.5 ± 15.39 | 37.3 ± 13.98 | 45.5 ± 15.74 | 20.2 ± 15.55 |
| Prodromal symptoms | ||||
| None | 191 (74%) | 140 (76%) | 49 (79.0%) | 2 (17%) |
| Fever | 20 (8%) | 9 (5%) | 5 (8%) | 6 (50.0%) |
| Malaise | 13 (5%) | 5 (3%) | 3 (5%) | 5 (42%) |
| Headache | 47 (18%) | 33 (18.0%) | 8 (13%) | 6 (50.0%) |
| Recent vaccination | 3 (1%) | 1 (0.5%) | 1 (2%) | 1 (8%) |
| Pregnancy | 2 (1%) | 2 (1%) | 0 (0.0%) | 0 (0.0%) |
| Index attack as a first demyelinating attack | 176 (69%) | 109 (60%) | 57 (93%) | 10 (83%) |
| Initial diagnosis | ||||
| Inflammatory demyelination | 182 (70%) | 136 (74%) | 37 (60%) | 9 (75%) |
| Malignancy | 54 (21%) | 35 (19%) | 18 (29%) | 1 (8%) |
| Vasculitis | 8 (3%) | 7 (4%) | 1 (1%) | 0 (0%) |
| Infection | 13 (5%) | 5 (3%) | 6 (9.5%) | 2 (16%) |
| History of pre‐existing autoimmune disorder | 20 (8%) | 16 (9.5%) | 2 (3%) | 2 (18%) |
| Duration of index attack | ||||
| <2 weeks | 24 (13%) | 18 (13%) | 4 (9%) | 2 (29%) |
| 2–6 weeks | 54 (29%) | 43 (31%) | 8 (18%) | 3 (43%) |
| 6–12 weeks | 40 (21%) | 31 (23%) | 9 (20%) | 0 (0.0%) |
| >12 weeks | 69 (37%) | 44 (32%) | 23 (52%) | 2 (29%) |
MOGAD, myelin oligodendrocytes glycoprotein antibody‐associated disease; N, number; SD, standard deviation; TD, tumefactive demyelination; TMS, tumefactive multiple sclerosis.