Table 4.
Radiological characteristics of initial MRI imaging in patients with tumefactive demyelination.
| Characteristics | All TD | TMS | TD | MOGAD | p value 1 |
|---|---|---|---|---|---|
| Solitary lesion | 56 (44%) | 33 (42%) | 20 (56%) | 3 (27%) | 0.06 |
| Balo lesion | 21 (17%) | 17 (21%) | 4 (11%) | 0 (0%) | |
| Multiple tumefactive lesion | 49 (39%) | 29 (37%) | 12 (33%) | 8 (73%) | |
| Butterfly lesion | 9 (7%) | 3 (4%) | 4 (11%) | 2 (20%) | 0.1 |
| Mean index lesion size ± SD (mm) | 20.3 ± 7.0 | 20.0 ± 6.8 | 21.4 ± 8 | 19.2 ± 5.7 | 0.7 |
| Focus of index lesion | |||||
| Frontal | 54 (42%) | 37 (47%) | 16 (43%) | 1 (9%) | 0.06 |
| Parietal | 39 (31%) | 27 (34%) | 11 (30%) | 1 (9%) | 0.2 |
| Temporal | 12 (9%) | 5 (6%) | 4 (11%) | 3 (27%) | 0.08 |
| Occipital | 15 (12%) | 8 (10%) | 6 (16%) | 1 (9%) | 0.6 |
| Cerebellum | 9 (7%) | 6 (8%) | 1 (3%) | 2 (18%) | 0.2 |
| Brainstem | 7 (5%) | 4 (5%) | 1 (3%) | 2 (18%) | 0.1 |
| Mass effect | 0.5 | ||||
| None | 68 (54%) | 44 (56%) | 16 (43%) | 8 (80%) | |
| Mild | 43 (34%) | 25 (32%) | 16 (43%) | 2 (20%) | |
| Moderate | 13 (10%) | 8 (10%) | 5 (13%) | 0 (0%) | |
| Severe | 1 (1%) | 1 (1%) | 0 (0%) | 0 (0%) | |
| Number of enhancing lesions ± SD | 2.9 ± 3.8 | 3.3 ± 4.1 | 2.4 ± 3.2 | 1.7 ± 2.5 | 0.13 |
| Number of FLAIR lesion ± SD | 4.7 ± 3.3 | 5.1 ± 3.6 | 3.4 ± 2.5 | 5.6 ± 2.34 | 0.01 |
| Fulfillment of Barkhof criteria | 59 (48%) | 41 (53%) | 13 (35%) | 5 (50%) | 0.2 |
| T2 hypointense rim | 30 (24%) | 8 (22%) | 20 (26%) | 2 (20%) | 0.87 |
| T1 hypointensity | 106 (88%) | 68 (89%) | 31 (89%) | 7 (70%) | 0.2 |
| ADC restriction | 59 (59%) | 38 (59%) | 19 (68%) | 2 (25%) | 0.09 |
ADC, apparent diffusion coefficient; FLAIR, Fluid‐attenuated inversion recovery; MOGAD, myelin oligodendrocytes glycoprotein antibody‐associated disease; N, number; TD, tumefactive demyelination; TMS, tumefactive multiple sclerosis.
1
Chi‐Square p‐value and Kruskal‐Wallis between TMS, TD and MOGAD groups.