Table 2.
HLA association in isolated REM sleep behavior disorder.
| MAF in cases | MAF in controls | OR | 95% CI | p | p (FDR) | |
|---|---|---|---|---|---|---|
| Alleles | ||||||
| HLA‐DRB1*11:01 | 0.0726 | 0.0472 | 1.57 | 1.27–1.93 | 2.70e‐05 | 2.75e‐03 |
| Amino acids | ||||||
| HLA‐DRB1 70D | 0.505 | 0.444 | 1.26 | 1.12–1.41 | 8.76e‐05 | 2.09e‐02 |
| HLA‐DRB1 70Q | 0.440 | 0.503 | 0.81 | 0.72–0.91 | 3.65e‐04 | 4.41e‐02 |
| HLA‐DRB1 71R | 0.545 | 0.496 | 1.21 | 1.08–1.35 | 1.35e‐03 | 4.41e‐02 |
| Haplotype | ||||||
| DQA1*05:01–DQB1*03:01–DRB1*11:01 | 0.0924 | 0.0657 | 1.40 | 1.16–1.70 | 5.17e‐04 | 2.85e‐02 |
| DQA1*05:01–DRB1*11:01 | 0.0933 | 0.0652 | 1.41 | 1.16–1.72 | 5.43e‐04 | 2.85e‐02 |
| DQB1*03:01–DRB1*11:01 | 0.0989 | 0.0707 | 1.36 | 1.13–1.64 | 1.04e‐03 | 3.64e‐02 |
CI, confidence interval; FDR, false discovery rate for each group; MAF, minor allele frequency; OR, odds ratio; p, p‐value.