Table 2. Toxic Effects for the Total Study Cohort.

Toxic effect	CTCAE grade, No. (%) (N = 217)a
	2	3	4	5
Worst overall	28 (13)	7 (3)	2 (1)	1 (1)
Pneumonitis	13 (6)	2 (1)	1 (1)	0
Noncardiac chest painb	11 (5)	2 (1)	0	0
Pleural effusion	4 (2)	1 (1)	0	0
Esophagitis	3 (1)	0	0	0
Otherc	5 (2)	3 (1)d	1 (1)	1 (1)

Abbreviation: CTCAE, Common Terminology Criteria for Adverse Events.

^a CTCAE version 4.0: grade 2 = moderate, 3 = severe, 4 = life threatening, and 5 = death.

^b Chest pain was generally due to chest wall pain or rib fracture.

^c The grade 5 toxic effect was a pulmonary hemorrhage possibly related to radiotherapy, and the grade 4 toxic effect was pneumonia probably related to radiotherapy.

^d One patient had grade 3 chest wall necrosis related to cryoablation for a lung tumor not treated on this study. The area of necrosis extended into the study radiation field but was graded as unrelated to study treatment since it was centered at the cryoablation site, outside the radiation field, and happened shortly after cryoablation.