Table 1.

Change in cfu/coverslip of intracellular M. abscessus over time treated with omadacycline and comparators

Organism	Multiple of the MIC	Δ log10 cfu/coverslip relative to untreated control at 0 h
		Omadacycline			Tigecycline			Amikacin			Clarithromycin
		24 h	48 h	72 h	24 h	48 h	72 h	24 h	48 h	72 h	24 h	48 h	72 h
M. abscessus ATCC 19799	0.25×	0.5	1.0	2.1	1.2	1.1	2.2	0.3	0.9	2.2	0.3	0.5	0.7
	1×	0.3	1.0	1.7	1.2	1.2	2.3	0.0	0.4	1.8	0.1	0.3	0.6
	4×	−0.2	0.3	0.6	0.2	0.6	0.9	0.0	0.2	0.1	0.3	0.3	0.4
	16×	−0.6	−1.0	−1.1	−0.7	−0.7	−1.4	−0.2	−0.1	0.0	0.1	0.0	0.2
M. abscessus MMX 9450	0.25×	0.3	0.4	1.1	0.3	0.7	1.4	0.4	0.8	1.2	0.3	0.3	0.5
	1×	0.1	0.2	0.4	0.0	0.2	0.2	0.3	0.5	0.7	0.3	0.4	0.4
	4×	−0.6	−0.6	−0.8	−1.0	−1.0	−1.1	0.3	0.4	0.5	0.3	0.2	0.4
	16×	−1.3	−1.4	−1.6	−1.1	−1.7	−2.3	0.3	0.3	0.3	0.1	0.1	0.1

Bold text denotes  ≥ 1-log killing. Mean Δlog10 determined by the change in cfu/mL versus the starting intracellular cfu (0 h timepoint) from sampling triplicate wells of each condition. The difference in mean log₁₀ cfu/coverslip recovered for two intracellular NTM isolates treated with multiples of the MIC of omadacycline, tigecycline, amikacin and clarithromycin over time versus the starting intracellular cfu.