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. 2023 Jul 11;10(26):2302425. doi: 10.1002/advs.202302425

Figure 1.

Figure 1

Elevated ALDOA levels correlate with a poor prognosis in HCC patients. a) Venn diagram showing the overlap between the oncogenic metabolic genes identified by CRISPR/Cas9 screening and the genes with elevated levels, which were statistically correlated with poor overall survival and Ki67 staining. b) The correlation between metabolic gene expression and MKI67 expression was determined in the GEPIA dataset. Statistical analysis was performed using Spearman's correlation analysis. c) Significant decreases in proliferation score were observed in 16 liver cancer cell lines after knockout of individual metabolic enzyme genes from project Achilles. d,e) ALDOA mRNA expression between peritumor and tumor tissues in the TCGA_LIHC dataset (Non‐tumor, n = 50; Tumor, n = 50) (d) and GSE25097 dataset (Non‐tumor, n = 243; Tumor, n = 268) (e). Data are represented as mean ± SD. Unpaired Student's t‐test. f,g) Kaplan‐Meier overall survival curves for individuals with different ALDOA mRNA expression levels in the TCGA_LIHC dataset (low, n  =  180; high, n = 180) (f) or CHCC_HBV dataset (low, n  =  79; high, n = 79) (g) based on univariate Cox regression analysis. ****P < 0.0001.