Table 1.
Patient characteristics and unadjusted outcomes among ward patients with hospital-onset sepsis using the Centers for Disease Control and Prevention Adult Sepsis Event criteria
| CDC ASE | |
|---|---|
| No. of subjects | 1,672 |
| Patient characteristics | |
| Hospital of admission | |
| 1 | 1,221 (73) |
| 2 | 215 (13) |
| 3 | 122 (7) |
| 4 | 69 (4) |
| 5 | 45 (3) |
| Admission year | |
| 2017 | 314 (19) |
| 2018 | 680 (41) |
| 2019 | 678 (41) |
| Age, median (IQR) | 63 (54–71) |
| Male | 910 (54) |
| Race | |
| White | 1,095 (66) |
| Black | 428 (26) |
| Other* | 149 (9) |
| Latinx | 45 (3) |
| Admission diagnosis category | |
| Symptoms, signs, and abnormal clinical and laboratory findings, NOS | 456 (27) |
| Neoplasms | 291 (17) |
| Diseases of the circulatory system | 175 (10) |
| Diseases of the digestive system | 152 (9) |
| Certain infectious and parasitic diseases | 119 (7) |
| Injury, poisoning, and certain other consequences of external causes | 97 (6) |
| Factors influencing health status and contact with health services | 86 (5) |
| Diseases of the respiratory system | 62 (4) |
| Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | 57 (3) |
| Endocrine, nutritional, and metabolic diseases | 50 (3) |
| Diseases of the musculoskeletal system and connective tissue | 46 (3) |
| Diseases of the genitourinary system | 36 (2) |
| Diseases of the nervous system | 23 (1) |
| Other† | 22 (1) |
| Medicine service at time of sepsis onset | 1,372 (82) |
| Days from admission to sepsis onset, median (IQR) | 7.3 (3.8–12.7) |
| Quarter of sepsis onset | |
| January through March | 355 (21) |
| April through June | 341 (20) |
| July through September | 495 (30) |
| October through December | 481 (29) |
| SOFA score, median (IQR) | |
| At sepsis onset | 4 (3–6) |
| Maximum within 7 d of sepsis onset | 8 (5–11) |
| Vasopressors | |
| At sepsis onset‡ | 29 (2) |
| Any time within 7 d of sepsis onset | 669 (40) |
| Mechanical ventilation | |
| At sepsis onset‡ | 58 (3) |
| Any time within 7 d of sepsis onset | 568 (34) |
| Unadjusted outcomes | |
| Hours from sepsis onset to antimicrobial initiation, median (IQR) | |
| Overall | 4.1 (0.4–23.3) |
| Onset during day shift (7 a.m.–7 p.m.) | 2.7 (0.0–14.0) |
| Onset during night shift (7 a.m.–7 p.m.) | 8.3 (1.5–34.3) |
| Antimicrobials initiated within 1 h of sepsis onset | 479 (29) |
| Antimicrobials initiated within 3 h of sepsis onset | 751 (45) |
| In-hospital mortality | 320 (19) |
Definition of abbreviations: ASE = Adult Sepsis Event; CDC = Centers for Disease Control and Prevention; IQR = interquartile range; NOS = not otherwise specified; SOFA = Sequential Organ Failure Assessment.
All values are presented as n (%) unless otherwise specified.
Other: Asian, American Indian/Alaskan Native, Pacific Islander, mixed, unknown, other.
Other: mental, behavioral, and neurodevelopmental disorders; diseases of the eye and adnexa; diseases of the ear and mastoid process; pregnancy, childbirth, and the puerperium; diseases of the skin and subcutaneous tissue; congenital malformations, deformations, and chromosomal abnormalities. Each of these diagnoses represented <1% of the overall population and was derived from International Classification of Diseases-10 codes.
Includes new start of vasopressors or mechanical ventilation concurrent with sepsis onset.