Table 2.
Multivariable model of exposures associated with sarcoidosis risk in African Americans
| Cluster/Exposure | Odds Ratio (95% CI) |
|---|---|
| Smoking (ever smoked cigarettes) | 0.68 (0.58–0.80) |
| Farm/outdoor animals | |
| Other mammals | 3.05 (2.08–4.48) |
| Other animals | 0.98 (0.76–1.25) |
| Farming or ranching | 1.11 (0.82–1.50) |
| Cotton/vegetable dust | 1.32 (1.01–1.72) |
| Household pets | |
| Other birds | 1.32 (1.05–1.68) |
| Fish (tank >10 gal) | 0.62 (0.52–0.74 |
| Fish (tank <10 gal) | 0.60 (0.50–0.71) |
| Hairspray | 0.81 (0.68–0.95) |
| Metals | |
| Aluminum | 1.48 (1.11–1.98) |
| Insecticide | 1.20 (1.02–1.42) |
Definition of abbreviation: 95% CI = 95% confidence interval.
The model was constructed based on five component least absolute shrinkage and selection operator penalized logistic regression mixed models constructed using multiple imputation by chained equations to account for missing data. The final model was composed of those exposures that were included in a majority (i.e., three or more) of the five component models. All component models were adjusted for sex.