. Author manuscript; available in PMC: 2023 Sep 15.

Published in final edited form as: J Affect Disord. 2023 May 16;335:349–357. doi: 10.1016/j.jad.2023.05.042

Table 1.

Statistical results.

	Predictor	Estimate	Std. error	t-Value/z-value	p-Value
A: Treatment outcome, BMI
Response/TRD	Risk score	0.285	0.064	4.435	<0.0001^**
Response/TRD	BMI	0.025	0.014	1.725	0.085
B: Clinical and sociodemographic parameters
Suicidality (yes/no)	BMI	10.042	0.014	3.048	0.002^*
Suicidality (yes/no)	Risk Score	0.186	0.057	3.268	0.001^*
Hospitalization time (weeks)	BMI	0.18	0.065	2.776	0.006^*
	Age	0.078	0.023	3.456	0.0006^**
	Risk Score	1.669	0.267	6.244	<0.0001^**
Age of first episode (years)	BMI	0.206	0.081	−2.547	0.011^*
Age of first episode (years)	Sex	1.87	0.854	2.19	0.029^*
Number of MDEs	BMI	0.037	0.021	1.751	0.08
	Sex	−0.493	0.225	−2.192	0.029^*
	Age	0.019	0.007	2.64	0.008^*
Duration of MDE (weeks)	BMI	0.251	1.475	0.17	n.s.
Agoraphobia (yes/no)	BMI	0.069	0.025	2.723	0.006^*
Social phobia (yes/no)	BMI	0.069	0.033	2.103	0.035^*
PTSD (yes/no)	BMI	0.135	0.043	3.138	0.002^*
PTSD (yes/no)	Age	−0.06	0.026	−2.335	0.02^*
GAD (yes/no)	BMI	−0.005	0.022	−0.221	n.s.
Panic disorder (yes/no)	BMI	0.032	0.022	1.426	n.s.
OCD (yes/no)	BMI	0.029	0.067	0.434	n.s.
Psychotic symptoms (yes/no)	BMI	−0.006	0.032	−0.2	n.s.
Dysthymia (yes/no)	BMI	0.066	0.096	0.692	n.s.
C: MADRS items
# 1 Apparent Sadness, baseline	BMI	−0.002	0.007	−0.224	n.s.
# 1 Apparent Sadness, post-treatment	BMI	0.004	0.011	0.316	n.s.
# 2 Reported Sadness, baseline	BMI	0.002	0.006	0.381	n.s.
# 2 Reported Sadness, post-treatment	BMI	0.008	0.011	0.736	n.s.
# 3 Inner Tension, baseline	BMI	−0.011	0.007	−1.483	n.s.
# 3 Inner Tension, post-treatment	BMI	0.004	0.009	0.445	n.s.
# 4 Reduced Sleep, baseline	BMI	0.008	0.009	0.879	n.s.
# 4 Reduced Sleep, post-treatment	BMI	0.015	0.0116	1.261	n.s.
# 5 Appetite Reduction, baseline	BMI	−0.04	0.0114	−3.484	0.0005^**
	Age	0.022	0.004	5.368	<0.0001^**
	Risk Score	0.096	0.047	2.06	0.04
# 5 Appetite Reduction, post-treatment	BMI	−0.048	0.01	−4.963	<0.0001^**
	Age	0.012	0.003	3.569	0.0003^**
	Risk Score	0.19	0.039	4.802	<0.0001^**
# 6 Concentration, baseline	BMI	0.022	0.007	3.046	0.002^*
# 6 Concentration, baseline	Risk Score	0.096	0.0297	3.225	0.001^*
# 6 Concentration, post-treatment	BMI	0.023	0.01	2.44	0.015^*
# 6 Concentration, post-treatment	Risk score	0.171	0.04	4.314	<0.0001^**
# 7 Lassitude, baseline	BMI	0.016	0.007	2.322	0.02^*
# 7 Lassitude, baseline	Age	0.005	0.002	1.984	0.048^*
# 7 Lassitude, post-treatment	BMI	0.017	0.011	1.567	n.s.
# 8 Inability to Feel, baseline	BMI	0.012	0.008	1.589	n.s.
# 8 Inability to Feel, post-treatment	BMI	0.017	0.011	1.623	n.s.
# 9 Pessimistic Thoughts, baseline	BMI	−0.012	0.008	−1.524	n.s.
# 9 Pessimistic Thoughts, post-treatment	BMI	0.003	0.01	0.292	n.s.
# 10 Suicidal Ideation, baseline	BMI	0.023	0.012	1.964	0.05
	Sex	0.32	0.122	2.628	0.009^*
	Risk score	0.217	0.05	4.594	<0.0001^**
# 10 Suicidal Ideation, post-treatment	BMI	0.012	0.009	1.324	n.s.

A. Treatment outcome and BMI according to response status; non-response (i.e., treatment-resistant depression) was defined as insufficient reduction in MADRS score after two adequate antidepressant treatment trials. B. Clinical and sociodemographic parameters and their relationship to BMI controlled for sex, age, and weight gain risk due to medication. Variables were obtained from case report forms. Only significant results of covariates are shown. C. Exploratory MADRS sub-item analyses at retrospective baseline and post-treatment. The risk score represents risk of weight gain according to medication.

Abbreviations: BMI: body mass index; GAD: generalized anxiety disorder; MADRS: Montgomery–Åsberg Depression Rating Scale; MDE: major depressive episode; OCD: obsessive-compulsive disorder; PTSD: post-traumatic stress disorder; TRD: treatment resistant depression.

p < 0.05 uncorrected.

^**

Bonferroni corrected p-values.