Table 5.
Odds ratios for the combined association of estradiol quartiles and vitamin D quartiles with low SMM.
| Vitamin D and Estradiol | Unadjusted Model | Model 1 | Model 2 | Model 3 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95%CI) | P value | OR (95%CI) | P value | OR (95%CI) | P value | OR (95%CI) | P value | ||||
| VD Q1 + estradiol Q1 | 3.339 (1.506,7.404) | 0.003 | 2.140 (0.920,4.982) | 0.077 | 2.178 (0.936,5.073) | 0.071 | 2.466 (0.906,6.711) | 0.077 | |||
| VD Q1 + estradiol Q2 | 7.008 (3.061,6.048) | < 0.001 | 4.915 (2.035,11.871) | < 0.001 | 4.964 (2.054,11.996) | < 0.001 | 5.849 (2.012,17.004) | 0.001 | |||
| VD Q1 + estradiol Q3 | 4.818 (2.128,10.907) | < 0.001 | 3.651 (1.545,8.629) | 0.003 | 3.704 (1.566,8.758) | 0.003 | 5.068 (1.783,14.403) | 0.002 | |||
| VD Q1 + estradiol Q4 | 0.723 (0.232,2.249) | 0.575 | 0.756 (0.239,2.391) | 0.634 | 0.751 (0.237,2.377) | 0.626 | 1.031 (0.280,3.791) | 0.964 | |||
| VD Q2 + estradiol Q1 | 5.154 (2.387,11.130) | < 0.001 | 3.35 (1.485,7.556) | 0.004 | 3.393 (1.503,7.659) | 0.003 | 3.409 (1.290,9.006) | 0.013 | |||
| VD Q2 + estradiol Q2 | 4.452 (1.841,0.767) | 0.001 | 2.731 (1.078,6.918) | 0.034 | 2.742 (1.081,6.955) | 0.034 | 3.045 (0.911,9.359) | 0.052 | |||
| VD Q2 + estradiol Q3 | 2.058 (0.844,5.020) | 0.113 | 1.466 (0.579,3.712) | 0.419 | 1.493 (0.59,3.781) | 0.398 | 1.795 (0.600,5.369) | 0.295 | |||
| VD Q2 + estradiol Q4 | 0.655 (0.194,2.214) | 0.496 | 0.707 (0.208,2.410) | 0.580 | 0.715 (0.210,2.441) | 0.593 | 1.093 (0.278,4.298) | 0.899 | |||
| VD Q3 + estradiol Q1 | 2.703 (1.170,6.244) | 0.020 | 1.856 (0.772,4.458) | 0.167 | 1.879 (0.782,4.518) | 0.159 | 1.731 (0.611,4.902) | 0.302 | |||
| VD Q3 + estradiol Q2 | 1.711 (0.626,4.675) | 0.295 | 1.216 (0.429,3.449) | 0.714 | 1.243 (0.438,3.527) | 0.683 | 1.764 (0.536,5.804) | 0.350 | |||
| VD Q3 + estradiol Q3 | 3.012 (1.310,6.927) | 0.009 | 2.59 (1.096,6.121) | 0.030 | 2.662 (1.125,6.298) | 0.026 | 4.117 (1.420,11.934) | 0.009 | |||
| VD Q3 + estradiol Q4 | 0.681 (0.219,2.118) | 0.507 | 0.713 (0.227,2.237) | 0.563 | 0.731 (0.232,2.297) | 0.591 | 1.101 (0.295,4.135) | 0.882 | |||
| VD Q4 + estradiol Q1 | 3.219 (1.424,7.275) | 0.005 | 2.183 (0.926,5.147) | 0.074 | 2.256 (0.956,5.324) | 0.063 | 2.288 (0.295,4.135) | 0.109 | |||
| VD Q4 + estradiol Q2 | 2.849 (1.130,7.178) | 0.026 | 2.144 (0.818,5.615) | 0.121 | 2.191 (0.835,5.751) | 0.111 | 2.062 (0.643,6.620) | 0.224 | |||
| VD Q4 + estradiol Q3 | 1.816 (0.726,4.544) | 0.202 | 1.685 (0.654,4.339) | 0.280 | 1.721 (0.668,4.436) | 0.261 | 1.958 (0.626,6.122) | 0.248 | |||
| VD Q4 + estradiol Q4 | Reference | Reference | Reference | Reference | |||||||
Notes: Bold indicates statistical significance. The model 1 adjusted for age, residence, marital status, educational level, BMI and fat mass; Model 2 adjusted for model 1 and smoking status, drinking status, physical activity; Model 3 adjusted for model 2 and triglyceride, menopausal status, dietary energy