Table 2.
The results of Mendelian randomization analysis for SS on cancers
| Cancer types | No. of SNPs | IVW (fixed) | MR-Egger | Weighted median | |||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | ||
| Overall breast cancer | 11 | 0.9952 (0.9832, 1.0073) | 0.4344 | 0.9878 (0.9364, 1.0420) | 0.6620 | 0.9858 (0.9714, 1.0005) | 0.0576 |
| Luminal A-like breast cancer | 11 | 1.0103 (0.9894, 1.0316) | 0.3365 | 1.0082 (0.8706, 1.1676) | 0.9153 | 0.9845 (1.0146, 0.9553) | 0.3094 |
| Luminal B/HER2- positive-like breast cancer | 11 | 0.9788 (0.9344, 1.0253) | 0.3654 | 0.8944 (0.6941, 1.1526) | 0.4109 | 0.9506 (0.8922, 1.0128) | 0.1170 |
| Luminal B/HER2- negative-like breast cancer | 11 | 0.9630 (0.9251, 1.0024) | 0.0653 | 0.8975 (0.7576, 1.0633) | 0.2426 | 0.9464 (0.8939, 1.0019) | 0.0583 |
| HER2-enriched-like breast cancer | 11 | 0.9934 (0.9550, 1.0334) | 0.7434 | 0.9463 (0.8080, 1.1082) | 0.5105 | 0.9889 (0.9369, 1.0437) | 0.6848 |
| Triple-negative breast cancer | 11 | 1.0058 (0.9404, 1.0757) | 0.8662 | 0.9925 (0.7590, 1.2980) | 0.9576 | 0.9704 (0.8883, 1.0601) | 0.5056 |
| Overall lung cancer | 10 | 1.0223 (0.9743, 1.0727) | 0.3690 | 1.0226 (0.8071, 1.2958) | 0.8575 | 0.9797 (0.9111, 1.0535) | 0.5807 |
| Lung adenocarcinoma | 10 | 1.0488 (0.9738, 1.1296) | 0.2082 | 1.0716 (0.7869, 1.4593) | 0.6722 | 1.0579 (0.9559, 1.1707) | 0.2767 |
| Squamous cell lung cancer | 10 | 1.0343 (0.9595, 1.1149) | 0.3782 | 1.3105 (0.8374, 2.0508) | 0.2707 | 1.0607 (0.9390, 1.1982) | 0.3432 |
| Prostate cancer | 10 | 0.9972 (0.9960, 0.9985) | 2.45E − 05 | 0.9951 (0.9930, 0.9972) | 0.0019 | 0.9961 (0.9945, 0.9978) | 3.26E − 06 |
| Endometrial cancer | 12 | 0.9414 (0.9158, 0.9676) | 1.65E − 05 | 0.8955 (0.8514, 0.9418) | 0.0016 | 0.9201 (0.8876, 0.9538) | 5.72E − 06 |
| Lymphomas | 12 | 1.0010 (1.0007, 1.0012) | 2.26E − 11 | 1.0014 (1.0006, 1.0021) | 0.0070 | 1.0010 (1.0007, 1.0014) | 2.51E − 08 |
| Liver and bile duct cancer | 10 | 0.9999 (0.9997, 1.0000) | 0.0291 | 0.9999 (0.9997, 1.0001) | 0.2192 | 0.9998 (0.9997, 1.0000) | 0.0320 |
| Cancer of urinary tract | 12 | 0.9996 (0.9993, 0.9999) | 0.0038 | 0.9997 (0.9990, 1.0003) | 0.3394 | 0.9997 (0.9993, 1.0000) | 0.0531 |
| Thyroid cancer | 9 | 0.8832 (0.7031, 1.1094) | 0.2858 | 1.2858 (0.4942, 3.3454) | 0.6222 | 0.9877 (0.7223, 1.3506) | 0.9383 |
| Oral cavity and pharyngeal cancer | 10 | 1.1068 (1.0068.1.2167) | 0.0357 | 1.3041 (0.9847.1.7270) | 0.1011 | 1.1764 (1.0085.1.3723) | 0.0387 |
Abbreviations: CI confidence interval, IVW inverse variance weighted, MR Mendelian randomization, OR odds ratio, SS Sjögren’s syndrome