Table 5.
The causal effects between single SNP of Sjögren’s syndrome and cancers
| SNP | Endometrial cancer | Prostate cancer | Lymphomas | |||
|---|---|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |
| rs3135394 | 0.9194 (0.8850, 0.9551) | 1.55E − 05 | 0.9959 (0.9942, 0.9975) | 1.28E − 06 | 1.0012 (1.0008, 1.0016) | 4.41E − 10 |
| rs2293765 | 1.0810 (0.9400, 1.2430) | 0.2746 | 0.9946 (0.9881, 1.0012) | 0.1078 | 0.9994 (0.9979, 1.0009) | 0.4418 |
| rs10774671 | 0.9054 (0.8088, 1.0135) | 0.0842 | 0.9964 (0.9913, 1.0015) | 0.1673 | 0.9993 (0.9981, 1.0004) | 0.2095 |
| rs7210219 | 1.0245 (0.8835, 1.1880) | 0.7490 | 1.0044 (0.9974, 1.0113) | 0.2183 | 1.0020 (1.0005, 1.0036) | 0.0115 |
| rs11250098 | 1.0831 (0.8457, 1.3873) | 0.5271 | 1.0050 (0.9955, 1.0146) | 0.3039 | 0.9995 (0.9973, 1.0017) | 0.6470 |
| rs11085725 | 1.0692 (0.9345, 1.2232) | 0.3303 | 1.0030 (0.9967, 1.0093) | 0.3484 | 1.0017 (1.0003, 1.0031) | 0.0210 |
| rs3757387 | 0.8952 (0.8236, 0.9731) | 0.0093 | 0.9983 (0.9944, 1.0021) | 0.3798 | 1.0003 (0.9994, 1.0012) | 0.5284 |
| rs8071514 | 0.9262 (0.7752, 1.1067) | 0.3987 | 0.9964 (0.9883, 1.0046) | 0.3937 | 1.0006 (0.9987, 1.0024) | 0.5533 |
| rs2069235 | 1.1311 (0.9531, 1.3423) | 0.1585 | 1.0031 (0.9950, 1.0112) | 0.4565 | 0.9996 (0.9978, 1.0015) | 0.6880 |
| rs485497 | 0.9882 (0.8795, 1.1103) | 0.8414 | 0.9989 (0.9934, 1.0043) | 0.6841 | 1.0008 (0.9996, 1.0021) | 0.2029 |
| rs7119038 | 0.8896 (0.7882, 1.0040) | 0.0580 | NE | NE | NE | NE |
| rs2431697 | 0.9632 (0.8151, 1.1383) | 0.6600 | NE | NE | 1.0005 (0.9987, 1.0022) | 0.5907 |
Abbreviations: CI confidence interval, NE not estimate, OR odds ratio