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. 2023 Sep 14;17:108. doi: 10.1186/s13034-023-00647-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Overall changes in cognitive performance between groups at Days 0, 6, and 12, with significant differences in processing speed between groups at Days 6 and 12. A A significant increase in the score of processing speed in esketamine group from baseline to Days 6 and 12. B A significant increase in the score of working memory in esketamine group from baseline to Day 12. C No significant change of verbal learning in either group from baseline to Day 6 or 12. D No significant change of visual learning in either group from baseline to Day 6 or 12. Asterisk (*) represents significant difference between groups (*P < 0.05)