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. 2023 Sep 14;18:684. doi: 10.1186/s13018-023-04188-4

Table 2.

The association between dietary folate intake and BMD

Dietary folate intake (quintile) Model 1 Model 2 Model 3 Model 4
β (95% CI) P value β (95% CI) P value β (95% CI) P value β (95% CI) P value
Total femur, gm/cm2
 Q1 Reference Reference Reference Reference
 Q2 0.006 (− 0.003, 0.015) 0.180  − 0.002 (− 0.010, 0.006) 0.636  − 0.002 (− 0.010, 0.006) 0.597  − 0.003 (− 0.010, 0.005) 0.519
 Q3 0.032 (0.023, 0.041)  < 0.001 0.009 (0.001, 0.017) 0.024 0.008 (0.000, 0.016) 0.038 0.007 (− 0.001, 0.015) 0.092
 Q4 0.046 (0.038, 0.055)  < 0.001 0.008 (− 0.000, 0.016) 0.051 0.011 (0.003, 0.019) 0.010 0.010 (0.002, 0.018) 0.017
 P trend  < 0.001 0.011 0.001 0.003
Femoral neck, gm/cm2
 Q1 Reference Reference Reference Reference
 Q2 0.001 (− 0.008, 0.009) 0.891  − 0.002 (− 0.009, 0.006) 0.681  − 0.002 (− 0.010, 0.005) 0.596  − 0.002 (− 0.010, 0.006) 0.595
 Q3 0.022 (0.013, 0.030)  < 0.001 0.007 (− 0.001, 0.014) 0.080 0.005 (− 0.002, 0.013) 0.164 0.004 (− 0.004, 0.012) 0.285
 Q4 0.030 (0.022, 0.039)  < 0.001 0.007 (− 0.001, 0.015) 0.071 0.008 (0.001, 0.016) 0.035 0.008 (− 0.000, 0.016) 0.052
 P trend  < 0.001 0.022 0.009 0.016
Trochanter, gm/cm2
 Q1 Reference Reference Reference
 Q2  − 0.003 (− 0.011, 0.006) 0.528  − 0.005 (− 0.013, 0.004) 0.285  − 0.004 (− 0.013, 0.004) 0.316  − 0.004 (− 0.013, 0.005) 0.415
 Q3 0.012 (0.004, 0.020) 0.005 0.003 (− 0.005, 0.012) 0.448 0.004 (− 0.005, 0.013) 0.354 0.005 (− 0.004, 0.014) 0.296
 Q4 0.018 (0.009, 0.026)  < 0.001 0.003 (− 0.006, 0.011) 0.563 0.004 (− 0.005, 0.014) 0.332 0.005 (− 0.004, 0.014) 0.267
 P trend  < 0.001 0.276 0.132 0.109
Intertrochanter, gm/cm2
 Q1 Reference Reference Reference Reference
 Q2 0.006 (− 0.001, 0.013) 0.100  − 0.001 (− 0.008, 0.006) 0.839  − 0.001 (− 0.008, 0.006) 0.763  − 0.002 (− 0.009, 0.005) 0.666
 Q3 0.027 (0.020, 0.035)  < 0.001 0.010 (0.003, 0.017) 0.005 0.008 (0.001, 0.015) 0.017 0.007 (− 0.000, 0.014) 0.050
 Q4 0.040 (0.033, 0.047)  < 0.001 0.010 (0.003, 0.017) 0.005 0.011 (0.004, 0.018) 0.003 0.011 (0.003, 0.018) 0.004
 P trend  < 0.001 0.001 0.000 (0.000, 0.000) 0.000 0.000
Total spine area, gm/cm2
 Q1 Reference Reference Reference Reference
 Q2 0.005 (− 0.005, 0.016) 0.304  − 0.004 (− 0.014, 0.005) 0.360  − 0.004 (− 0.013, 0.005) 0.365  − 0.005 (− 0.014, 0.004) 0.291
 Q3 0.034 (0.024, 0.044)  < 0.001 0.007 (− 0.002, 0.017) 0.140 0.007 (− 0.003, 0.016) 0.165 0.005 (− 0.005, 0.014) 0.320
 Q4 0.050 (0.040, 0.060)  < 0.001 0.005 (− 0.005, 0.015) 0.318 0.009 (− 0.001, 0.018) 0.073 0.008 (− 0.002, 0.017) 0.128
 P trend  < 0.001 0.117 0.016 0.033

Model 1 Crude model

Model 2 Adjusted for age, sex, race, PIR, and marital status

Model 3 Adjusted for age, sex, race, PIR, marital status, BMI, hypertension, serum cotinine, physical activity, and alcohol use

Model 4 Adjusted for age, sex, race, PIR, marital status, BMI, hypertension, serum cotinine, physical activity, alcohol use, and total vitamin D

MET Metabolic equivalent, BMD Bone mineral density