Table 2.
The association between dietary folate intake and BMD
| Dietary folate intake (quintile) | Model 1 | Model 2 | Model 3 | Model 4 | ||||
|---|---|---|---|---|---|---|---|---|
| β (95% CI) | P value | β (95% CI) | P value | β (95% CI) | P value | β (95% CI) | P value | |
| Total femur, gm/cm2 | ||||||||
| Q1 | Reference | Reference | Reference | Reference | ||||
| Q2 | 0.006 (− 0.003, 0.015) | 0.180 | − 0.002 (− 0.010, 0.006) | 0.636 | − 0.002 (− 0.010, 0.006) | 0.597 | − 0.003 (− 0.010, 0.005) | 0.519 |
| Q3 | 0.032 (0.023, 0.041) | < 0.001 | 0.009 (0.001, 0.017) | 0.024 | 0.008 (0.000, 0.016) | 0.038 | 0.007 (− 0.001, 0.015) | 0.092 |
| Q4 | 0.046 (0.038, 0.055) | < 0.001 | 0.008 (− 0.000, 0.016) | 0.051 | 0.011 (0.003, 0.019) | 0.010 | 0.010 (0.002, 0.018) | 0.017 |
| P trend | < 0.001 | 0.011 | 0.001 | 0.003 | ||||
| Femoral neck, gm/cm2 | ||||||||
| Q1 | Reference | Reference | Reference | Reference | ||||
| Q2 | 0.001 (− 0.008, 0.009) | 0.891 | − 0.002 (− 0.009, 0.006) | 0.681 | − 0.002 (− 0.010, 0.005) | 0.596 | − 0.002 (− 0.010, 0.006) | 0.595 |
| Q3 | 0.022 (0.013, 0.030) | < 0.001 | 0.007 (− 0.001, 0.014) | 0.080 | 0.005 (− 0.002, 0.013) | 0.164 | 0.004 (− 0.004, 0.012) | 0.285 |
| Q4 | 0.030 (0.022, 0.039) | < 0.001 | 0.007 (− 0.001, 0.015) | 0.071 | 0.008 (0.001, 0.016) | 0.035 | 0.008 (− 0.000, 0.016) | 0.052 |
| P trend | < 0.001 | 0.022 | 0.009 | 0.016 | ||||
| Trochanter, gm/cm2 | ||||||||
| Q1 | Reference | Reference | Reference | |||||
| Q2 | − 0.003 (− 0.011, 0.006) | 0.528 | − 0.005 (− 0.013, 0.004) | 0.285 | − 0.004 (− 0.013, 0.004) | 0.316 | − 0.004 (− 0.013, 0.005) | 0.415 |
| Q3 | 0.012 (0.004, 0.020) | 0.005 | 0.003 (− 0.005, 0.012) | 0.448 | 0.004 (− 0.005, 0.013) | 0.354 | 0.005 (− 0.004, 0.014) | 0.296 |
| Q4 | 0.018 (0.009, 0.026) | < 0.001 | 0.003 (− 0.006, 0.011) | 0.563 | 0.004 (− 0.005, 0.014) | 0.332 | 0.005 (− 0.004, 0.014) | 0.267 |
| P trend | < 0.001 | 0.276 | 0.132 | 0.109 | ||||
| Intertrochanter, gm/cm2 | ||||||||
| Q1 | Reference | Reference | Reference | Reference | ||||
| Q2 | 0.006 (− 0.001, 0.013) | 0.100 | − 0.001 (− 0.008, 0.006) | 0.839 | − 0.001 (− 0.008, 0.006) | 0.763 | − 0.002 (− 0.009, 0.005) | 0.666 |
| Q3 | 0.027 (0.020, 0.035) | < 0.001 | 0.010 (0.003, 0.017) | 0.005 | 0.008 (0.001, 0.015) | 0.017 | 0.007 (− 0.000, 0.014) | 0.050 |
| Q4 | 0.040 (0.033, 0.047) | < 0.001 | 0.010 (0.003, 0.017) | 0.005 | 0.011 (0.004, 0.018) | 0.003 | 0.011 (0.003, 0.018) | 0.004 |
| P trend | < 0.001 | 0.001 | 0.000 (0.000, 0.000) | 0.000 | 0.000 | |||
| Total spine area, gm/cm2 | ||||||||
| Q1 | Reference | Reference | Reference | Reference | ||||
| Q2 | 0.005 (− 0.005, 0.016) | 0.304 | − 0.004 (− 0.014, 0.005) | 0.360 | − 0.004 (− 0.013, 0.005) | 0.365 | − 0.005 (− 0.014, 0.004) | 0.291 |
| Q3 | 0.034 (0.024, 0.044) | < 0.001 | 0.007 (− 0.002, 0.017) | 0.140 | 0.007 (− 0.003, 0.016) | 0.165 | 0.005 (− 0.005, 0.014) | 0.320 |
| Q4 | 0.050 (0.040, 0.060) | < 0.001 | 0.005 (− 0.005, 0.015) | 0.318 | 0.009 (− 0.001, 0.018) | 0.073 | 0.008 (− 0.002, 0.017) | 0.128 |
| P trend | < 0.001 | 0.117 | 0.016 | 0.033 | ||||
Model 1 Crude model
Model 2 Adjusted for age, sex, race, PIR, and marital status
Model 3 Adjusted for age, sex, race, PIR, marital status, BMI, hypertension, serum cotinine, physical activity, and alcohol use
Model 4 Adjusted for age, sex, race, PIR, marital status, BMI, hypertension, serum cotinine, physical activity, alcohol use, and total vitamin D
MET Metabolic equivalent, BMD Bone mineral density