Table 2.

Weighted linear regression showing the relationship between LE8/CVH and biological ageing

	Crude model		Model 1		Model 2
	β (95%CI)	P	β (95%CI)	P	β (95%CI)	P
	Phenotypic age
LE8	− 0.450 (− 0.487, − 0.413)	< 0.0001	− 0.170 (− 0.181, − 0.158)	< 0.0001	− 0.129 (− 0.142, − 0.117)	< 0.0001
CVH
Low	ref		ref		ref
Moderate	− 10.505 (− 11.744, − 9.267)	< 0.0001	− 4.730 (− 5.325, − 4.135)	< 0.0001	− 3.047 (− 3.596, − 2.498)	< 0.0001
High	− 20.118 (− 21.734, − 18.502)	< 0.0001	− 7.406 (− 7.953, − 6.858)	< 0.0001	− 5.268 (− 5.831, − 4.705)	< 0.0001
P for trend		< 0.0001		< 0.0001		< 0.0001
	Biological age
LE8	− 0.435 (− 0.465, − 0.405)	< 0.0001	− 0.187 (− 0.197, − 0.177)	< 0.0001	− 0.117 (− 0.127, − 0.107)	< 0.0001
CVH
Low	ref		ref		ref
Moderate	− 9.966 (− 11.172, − 8.760)	< 0.0001	− 5.101 (− 5.628, − 4.573)	< 0.0001	− 2.94 (− 3.381, − 2.498)	< 0.0001
High	− 19.347 (− 20.765, − 17.930)	< 0.0001	− 8.098 (− 8.697, − 7.498)	< 0.0001	− 4.76 (− 5.303, − 4.217)	< 0.0001
P for trend		< 0.0001		< 0.0001		< 0.0001
	PhenoAgeAccel
LE8	− 0.193 (− 0.204, − 0.182)	< 0.0001	− 0.170 (− 0.181, − 0.158)	< 0.0001	− 0.129 (− 0.142, − 0.117)	< 0.0001
CVH
Low	ref		ref		ref
Moderate	− 5.413 (− 6.007, − 4.819)	< 0.0001	− 4.73 (− 5.325, − 4.135)	< 0.0001	− 3.047 (− 3.596, − 2.498)	< 0.0001
High	− 8.788 (− 9.312, − 8.264)	< 0.0001	− 7.406 (− 7.953, − 6.858)	< 0.0001	− 5.268 (− 5.831, − 4.705)	< 0.0001
P for trend		< 0.0001		< 0.0001		< 0.0001
	BioAgeAccel
LE8	− 0.178 (− 0.189, − 0.166)	< 0.0001	− 0.187 (− 0.197, − 0.177)	< 0.0001	− 0.117 (− 0.127, − 0.107)	< 0.0001
CVH
Low	ref		ref		ref
Moderate	− 4.874 (− 5.429, − 4.320)	< 0.0001	− 5.101 (− 5.628, − 4.573)	< 0.0001	− 2.94 (− 3.381, − 2.498)	< 0.0001
High	− 8.017 (− 8.655, − 7.379)	< 0.0001	− 8.098 (− 8.697, − 7.498)	< 0.0001	− 4.76 (− 5.303, − 4.217)	< 0.0001
P for trend		< 0.0001		< 0.0001		< 0.0001

Crudel model: unadjusted model;

Model 1: Adjusted for age, sex, race, marital status, education, poverty-income ratio, and alcohol using;

Model 2: Additionally adjusted for hypertension, CVD, diabetes, and cancer

LE8, life’s essential 8; CVH, cardiovascular health; PhenoAgeAccel, phenotypic age acceleration; BioAgeAccel, biological age acceleration

Low CVH was defined as a LE8 score of 0 to 49, moderate CVH of 50–79, and high CVH of 80–100