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. 2023 Sep 15;17:85. doi: 10.1186/s40246-023-00532-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Summary of the results of the RTT-MECP2 versus healthy controls analysis. A RNAseq DE analysis results. The coloured genes are considered differentially expressed, passing a threshold of BH < 0.05. B Upstream TF ChEA3 analysis for the DEGs. The 40 TFs that were further studied are coloured in black. C Proteomics DE analysis results. The coloured proteins are considered differentially expressed, passing a threshold of nominal p value < 0.05. D) An integrated view of the transcriptomics and proteomics results. The genes that are significant at both analyses are coloured in purple