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. 2023 Sep 15;17:85. doi: 10.1186/s40246-023-00532-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Summary of the common findings between the analysis of female RTT-MECP2 patients versus female controls and male MDS patients versus male controls. A Enrichment analysis results for the shared 82 DEGs downregulated in RTT and upregulated in MDS, coloured by Biological Process (BP). B Enrichment analysis results for the shared 100 DEGs upregulated in RTT and downregulated in MDS coloured by BP. C Relevant TF from ChEA3 analysis for the 82 and 100 DEGs dysregulated at transcriptomic level coloured by BP. D Transcriptomics DE analysis results. The common 182 DEGs expressed in opposite directions are coloured by BP. E Common 12 DEPs coloured by BP. F Common DEGs and DEPs obtained from a multi-omics approach