Table 2.

Body composition and anthropometry.

	Control groupa (n = 52)	AI groupa (n = 52)	MAD (AI vs control) (95% CI)	P-valueb
Primary outcomes VAT (cm2)				0.79
0 months	133 (85.2; 164)	141 (100; 199)
6 months	124 (82.9; 170)	144 (94.7; 203)	−6.19 (−19.4; 7.07)
12 months	134 (83.7; 190)	164 (95.1; 227)	−4.84 (−18.0; 8.35)
24 months	129 (89.3; 190)	150 (106; 242)	−1.54 (−14.9; 11.9)
Weight (kg)				0.84
0 months	75.6 (67.0; 83.9)	74.4 (64.2; 88.6)
6 months	75.3 (66.1; 82.9)	70.9 (63.2; 88.8)	−0.15 (−1.65; 1.36)
12 months	74.4 (64.5; 87.6)	75.6 (64.8; 88.3)	−0.62 (−2.13; 0.90)
24 months	73.1 (65.8; 84.8)	75.0 (62.0; 89.2)	0.02 (−1.52; 1.55)
Waist circumference (cm)				0.36
0 months	96 (84.0, 106)	96 (86.5; 110)
6 months	96 (85.0; 104)	92 (86.0; 106)	−1.57 (−3.59; 0.46)
12 months	93 (84.0; 103)	94 (80.5; 106)	−1.09 (−3.15; 0.98)
24 months	92 (82.8; 102)	94 (82.0; 104)	−1.67 (−3.73; 0.39)
Fat mass (kg)				0.25
0 months	31.8 (27.3; 37.4)	33.2 (25.8; 40.1)
6 months	32.1 (27.5; 38.1)	32.5 (27.4; 41.7)	−1.35 (−2.67; −0.02)
12 months	33.5 (27.5; 39.6)	34.7 (26.1; 41.2)	−0.90 (−2.22; 0.41)
24 months	32.6 (27.9; 40.4)	36.1 (27.4; 42.7)	−0.83 (−2.21; 0.55)
Lean mass (kg)				0.49
0 months	41.0 (36.4; 47.6)	39.8 (35.8; 45.3)
6 months	39.3 (36.9; 47.1)	40.5 (34.2; 46.3)	0.49 (−0.48; 1.47)
12 months	39.3 (36.1; 44.9)	40.0 (35.9; 44.6)	0.35 (−0.63; 1.32)
24 months	38.2 (35.3; 42.6)	38.6 (35.3; 44.1)	0.78 (−0.22; 1.78)
SAT (cm2)				0.42
0 months	361 (288; 480)	387 (327; 483)
6 months	363 (316; 482)	399 (312; 466)	−18.1 (−39.7; 3.6)
12 months	404 (317; 494)	419 (333; 507)	−5.8 (−27.3; 15.7)
24 months	377 (334; 502)	437 (320; 510)	−4.1 (−25.9; 17.8)

^aCrude values are presented as median (IQR).

^bThe significance level was tested as a single P-value between groups over all time points (see section Methods for details).

AI, aromatase inhibitor; MAD, mean adjusted difference; SAT, subcutaneous adipose tissue; VAT, visceral adipose tissue.