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(A) Friedel–Crafts approach to KR-1. a(1 eq.), 2-methylbenzoyl chloride (1.1 eq.), AlCl3 (1.75 eq.), solvent (2–2.5 M). b1 (1 eq.), 2-methylbenzoyl chloride (1.1 eq.), Lewis acid (1.75 eq.) and CH2Cl2 (2 M). (B) Organolithium-mediated approach to KR-2 and KR-3. (C) Double Heck Approach to KR-4. See Sections S3 and S4 for detailed synthetic procedures and analysis.
