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. 2023 Sep 14;12(1):2253644. doi: 10.1080/2162402X.2023.2253644

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 3. — Effect of ICI immunotherapy on circulating immunological profile in NSCLC patients.

(a) t-distributed stochastic neighbor embedding (t-SNE) analysis on flow cytometry events following debris and doublet exclusion in non-progressor (NP) and progressor (P) patients before (T0) and after (T1) ICI treatment (T0-P and -NPn = 15, T1-P n = 9, T1-NPn = 15). Pie charts representing cell population proportions derived from clustering and t-SNE analysis for each group and time point. (b) Monocytes, PMNs, lymphocytes, T, B, and NK cell count in progressor (P, red) and non-progressor (NP, green) NSCLC patients before (T0) and after (T1) ICI treatment (n = 34). Mann–Whitney test. The data are shown as the mean ± SEM. *p < .05. Stars and lines related to statistical analyses are indicated in: red for comparison between T0 and T1 in Progressor (P) patients; green for comparison between T0 and T1 in Non-Progressor (NP) patients; black for comparison between P and NP patients at either T0 (left) or T1 (right), respectively.