Table 2.
Frequency and Composition Ratio of KRAS/NRAS/BRAF/PIK3CA Mutation in CRC Patients
| Gene Name | Exon | Number and Frequency of Mutation (n,%) | Composition Ratio of Mutations |
|---|---|---|---|
| KRAS | Exon2 | 135(33.1%) | 62.5% |
| Exon3 | 11(2.7%) | 5.1% | |
| Exon4 | 15(3.7%) | 6.9% | |
| NRAS | Exon2 | 7(1.7%) | 3.2% |
| Exon3 | 3(0.7%) | 1.4% | |
| BRAF | Exon15 | 9(2.2%) | 4.2% |
| PIK3CA | Exon9 | 6(1.5%) | 2.8% |
| Exon20 | 1(0.2%) | 0.5% | |
| KRAS and NRAS | KRAS exon2 and NRAS exon2 | 1(0.2%) | 0.5% |
| KRAS and BRAF | KRAS exon2 and BRAF exon15 | 1(0.2%) | 0.5% |
| KRAS and PIK3CA | KRAS exon2 and PIK3CA exon9 | 17(4.2%) | 7.9% |
| KRAS exon2 and PIK3CA exon20 | 8(2.0%) | 3.7% | |
| KRAS exon3 and PIK3CA exon9 | 1(0.2%) | 0.5% | |
| KRAS exon3 and PIK3CA exon20 | 1(0.2%) | 0.5% | |
| Total | 216(52.9%) | 100.0% |