Table 3.

Clinicopathological Characteristics According to KRAS/NRAS/BRAF/PIK3CA Gene Mutation Status in CRC Patients

	KRAS (Exon2/3/4)			NRAS (exon2/3)			BRAF (Exon15)			PIK3CA (Exon9/20)
	Normal (n=218)	Mutated (n=190)	P value	Normal (n=397)	Mutated (n=11)	P value	Normal (n=398)	Mutated (n=10)	P value	Normal (n=374)	Mutated (n=34)	P value
Gender
Male	144	112	0.151	249	7	1.000	251	5	0.510	240	16	0.063
Female	74	78		148	4		147	5		134	18
Age
<60	97	88	0.765	179	6	0.556	180	5	0.761	173	12	0.281
≥60	121	102		218	5		218	5		201	22
Tumor site
Colon	117	110	0.682	223	4	0.340	219	8	0.309	208	19	1.000
Rectum	98	77		168	7		173	2		160	15
Cecum	3	3		6	0		6	0		6	0
Maximum diameter of tumor
<5cm	135	120	0.916	248	7	1.000	251	4	0.288	232	23	0.851
≥5cm	72	66		135	3		133	5		127	11
Tumor differentiation
Well	1	3	0.388	3	1	0.112	4	0	0.012	4	0	0.121
Moderate	201	169		360	10		364	6		342	28
Poor	16	18		34	0		30	4		28	6
Lymphovascular invasion
Present	43	37	1.000	80	0	0.132	75	5	0.029	73	7	0.824
Absent	175	153		317	11		323	5		301	27
Perineural invasion
Present	25	29	0.306	54	0	0.373	52	2	0.628	52	2	0.288
Absent	193	161		343	11		346	8		322	32
Disease stage at diagnosis
I-III	178	139	0.043	310	7	0.273	310	7	0.699	288	29	0.294
IV	40	51		87	4		88	3		86	5
Lymph node metastasis
No	104	73	0.071	175	2	0.124	174	3	0.524	164	13	0.590
Yes	114	117		222	9		224	7		210	21
Distant metastasis
No	179	138	0.024	310	7	0.273	310	7	0.699	288	29	0.294
Yes	39	52		87	4		88	3		86	5
MMR
pMMR	200	180	1.000	370	10	1.000	371	9	1.000	350	30	0.121
dMMR	8	7		15	0		15	0		12	3

Note: Bold values for P<0.05.