Table 4.

Multivariate Logistic Regression in CRC Patients Between Gene Mutations and Clinicopathological Characteristics

Characteristics	KRAS			NRAS			BRAF			PIK3CA
	Adjusted Odds Ratio (95% CI)	R2	P value	Adjusted Odds Ratio (95% CI)	R2	P value	Adjusted Odds Ratio (95% CI)	R2	P value	Adjusted Odds Ratio (95% CI)	R2	P value
Gender (Male/Female)	0.691(0.450–1.061)	0.154	0.091	2.252(0.425–11.947)	0.164	0.340	0.555(0.120–2.562)	0.250	0.450	0.443(0.210–0.934)	0.181	0.032
Age (≥60/<60)	0.915(0.605–1.383)		0.673	0.956(0.241–3.799)		0.950	0.778(0.157–3.856)		0.759	1.723(0.798–3.720)		0.166
Tumor site (Colon/Other)	1.191(0.769–1.845)		0.434	0.298(0.065–1.362)		0.119	3.325(0.346–31.990)		0.298	1.093(0.496–2.407)		0.825
Maximum diameter of tumor (≥5cm/<5cm)	0.992(0.633–1.555)		0.971	1.325(0.294–5.969)		0.714	2.362(0.476–11.727)		0.293	0.896(0.394–2.035)		0.792
Tumor differentiation (Poor/Moderate+well)	1.646(0.729–3.717)		0.231	–		0.998	7.224(1.356–38.488)		0.021	3.811(1.268–11.455)		0.017
Lymphovascular invasion (Present/Absent)	0.745(0.423–1.314)		0.310	–		0.997	4.547(0.874–23.666)		0.072	0.968(0.365–2.567)		0.948
Perineural invasion (Present/Absent)	1.897(0.962–3.738)		0.064	–		0.997	0.553(0.054–5.640)		0.617	0.387(0.083–1.808)		0.227
Distant metastasis (Yes/No)	1.675(1.017–2.760)		0.043	5.183(1.239–21.687)		0.024	0.495(0.075–3.265)		0.465	0.512(0.184–1.428)		0.201

Notes: P< 0.05 was considered statistically significant. Bold values for P<0.05.

Abbreviation: CI, confidence interval.