Table 3.

Distinct genomic cargoes and effects identified in exosomes from central nervous system cells in neurodegenerative disorders

Genomic cargo	Cell types	Effects	References
miR-1	NSC	Increases hippocampal neurogenesis	Micci et al., 2019
miR-17-92	MSC	Reducing binding of Aβ to synapses increases synaptic resistance protectingtheprotecting the hippocampus from Aβ-induced LTP inhibition	Micci et al., 2019
miR-124	NSC	lnduced adult neurogenesis in the subventricular zone and regulated cell cyclein striatal neurons	Cheng et al., 2009
miR-124	NSC-34	Drives changes in microglial phenotype and suppresses inflammatory responses	Pinto et al., 2017
miR-322	NSC	Reducing binding of Aβ to synapses increases synaptic resistance protectingtheprotecting the hippocampus from Aβ-induced LTP inhibition	Micci et al., 2019

Aβ: Amyloid-beta; LTP: long-term potentiation; MSC: mesenchymal stem cell; NSC: neural stem cell.