Table 1.
Comparison of the lipoprotein composition of myelin in central and peripheral nervous systems
| Lipid composition | CNSa | PNSb | Protein composition | CNSc | PNSd |
|---|---|---|---|---|---|
| Cholesterol | 46% | 41% | Myelin basic protein | 8% | 18% |
| Phospholipids | 33% | 42% | Myelin associated glycoprotein | 1% | 0.20% |
| - Plasmalogen | 13% | 13% | Cyclic nucleotide phosphodiesterase | 4% | 0.30% |
| - Phosphatidylcholine | 7% | 10% | Proteolipid protein | 17% | 0.20% |
| - Sphingomyelin | 6% | 13% | Myelin oligodendrocytes glycoprotein | 1% | – |
| - Glycerophosphatides | 7% | 7% | Claudin 11 | 1% | – |
| Glycolipids | 20% | 12% | Peripheral myelin protein 2 | – | 0.30% |
| -Cerebroside (galactosylceramide) | 17% | 10% | Myelin protein 0 | – | 45% |
| - Sulphatide | 3% | 1% | Periaxin | – | 16% |
| Other lipids | 1% | 5% | Other proteins | 68% | 20% |
Table was adapted from Poitelon et al. (2020) and Nave and Werner (2014). Data obtained from aNorton and Autilio (1966), bO’Brien et al. (1967), cJahn et al. (2009), and dSiems et al. (2020). CNS: Central nervous system; PNS: peripheral nervous system.